ID A0A3P9PRA8_POERE Unreviewed; 1263 AA.
AC A0A3P9PRA8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DENN domain-containing protein 5B-like {ECO:0000313|Ensembl:ENSPREP00000024300.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000024300.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000024300.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000024300.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3P9PRA8; -.
DR Ensembl; ENSPRET00000024546.1; ENSPREP00000024300.1; ENSPREG00000016383.1.
DR GeneTree; ENSGT00940000153678; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000016383; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR CDD; cd17677; RUN1_DENND5; 1.
DR Gene3D; 1.20.58.900; -; 3.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR047278; DEN5A/B.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR46070:SF3; DENN DOMAIN-CONTAINING PROTEIN 5B; 1.
DR PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02759; RUN; 2.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00593; RUN; 2.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF140741; RUN domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50826; RUN; 2.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 53..602
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 792..952
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 1107..1258
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT REGION 153..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..714
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1263 AA; 140166 MW; C355ABAEC1BF23A5 CRC64;
MKTPATGGSA SCRFAHYFVV CGVDTETGLE PDDGAGKYAR FHLKRFGPVA VAEGGGMTSQ
SPIRRSFKSK VLVHYPENTD RNPFNKDAVN MLCLPRGLSF RTQVDSLDPQ FHSFTVTSDD
GTRSYGFVHT FYEEVTSPQI ITAMQTLYQM HHVEHHSSSS ASSPSSSTSS SASTPSASSM
DSLASSLEES DAESLTSGVS GCLGCIGSFD AARDTLYVSK ALCLITPLPF LHASQQFLAQ
LHQAVTSQTA PPLPLESYVY NILYEVPLPP PGRSLRFHGV QGPIVCQRPG PGELPLGDYP
LGEAFSLLGV DNMVKLLTCA LLETQVLLYS KDYQRLMMVA EGITTLLFPF QWQHIYLPII
STPLHHLLDA PVPFLMGIQH RNGAQRSSLH LPHEANLCFV DIDSHCVEAP EDLPLFPDQT
ELIQELSEVL LSFGLPPRGG VTTTTTAGST SASPRLSSLV LEDLMEDRRN GNLGGEELAA
LERLQALARR CGGGKVSEGG KTLGHVFEEE EEELKAAKLN IQLREVFAVR FSAIFGRYED
FIVNSAMDLD SWLNNRDGTC SFDKGSFLSV QPAAHLHFLS RFLETSMFSS FVDGKVVSRW
VDREPLQQLF DSRMERERLY DISDEESRNR PYRKCSTLFE SAQAIERRLL KTDHTAIHPH
LLDMRIGQGR HHPGYFPRLQ ADVLAQAHNT HKYSSRITAS RRTEPRRSAS DHSGSDGEPK
QVLTHTATHA GLKTFRQSKL LDPSPQAVSQ THREFVDGLL SECRLKTKRM LKERMGKECV
ELGQGEANIT GLQENTLIHG LCDLLERTWG HGLQIKQGKS AIWSHLLHYQ ATQEKMEAPA
DVPGSNSLDQ RLSDDGPLLL RGSLIQDMRF IQTMRDDMSE VGQARAWIHL ALEKKMLSQH
LKELLTHQEL LRQLYKPHAF LLCEEEREQF LYHLLSLNTV DYLCFTRTFT SISIPYRVVI
IPMKKLSIAM ATVNPWVCVS GELGDSGVRQ IPKNAQEIFF QNLGRLSTLQ LGVQENSGLL
AKCLIDCVVV YNEITGHTHR FPCGRWLGKG VGDGSLERVL IGQLVSPGAE EDAGRWSGTP
PELASPSQSV RTVLGSLGGM HSRGNLTVLL CGEGGLVLAL EKFLLHGFRS NRLFQRNVFV
WDFVEKAVVS METIDQMGDL HGSTLPKSPP CDSLCRYVHA INSSPRNIGK EGKFQLFVCL
GIRDRLLSQW FPLLAECPLT ARTYEDGALL RDRAALHSLC RILQTLNDFS ITLEAALVKG
VDL
//
