ID A0A3P9PRE5_POERE Unreviewed; 2013 AA.
AC A0A3P9PRE5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Dysferlin {ECO:0000313|Ensembl:ENSPREP00000024335.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000024335.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000024335.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000024335.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR STRING; 8081.ENSPREP00000024335; -.
DR Ensembl; ENSPRET00000024581.1; ENSPREP00000024335.1; ENSPREG00000016364.1.
DR GeneTree; ENSGT00940000156187; -.
DR OMA; DAYCSVT; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000016364; Expressed in head.
DR GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048644; P:muscle organ morphogenesis; IEA:Ensembl.
DR GO; GO:0001778; P:plasma membrane repair; IEA:Ensembl.
DR GO; GO:0033292; P:T-tubule organization; IEA:Ensembl.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546:SF44; DYSFERLIN; 1.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1971..1991
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 213..348
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 368..504
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1100..1226
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1264..1392
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1499..1617
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1723..1871
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 170..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1921..1943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 647..674
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1921..1941
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2013 AA; 229427 MW; 4981B9755D338BA7 CRC64;
MLRVFILCAE RLQTPDDDIS DAYCSVTYEG SKKKTKVIKN NPNPVWNEGF EWDLKGIPLD
SGAEIHCVVK DHEKMGRNRF LGESRLGLRD VLNSPNFAAT FTVSLLDTKR NNTGATLTLQ
VSYIPPPGSA PVFHPPSQPE TCPPVFHPVI SLDTLGEEDT ESMIMVEPAE EPGIDDSRSL
VIIGPPGPPG QESPTNQTPK RSPPAYNTHG GLRKRRRGAS SQPKPLANKP QDIQVRVRVV
EARQLPGVNI KPVVKVAVAG QTKRTRIRKG NNPVFDETFF LNFYETPSEL FDEPIFITVS
LNLDSESSFK LDVGTVYNEH RHCFLRKWLL LCDPDDLSAG VRGYLKVSVL VLAAGDEPPA
DKRECVEEKE DIEGNLLRPA GLSLRGAVFM LRIFRAEDLP QMDDAFMDGM RQILGFDTNR
KNLVDPLVEI HFAGKTVCTK ILEKNANPQW NQSLAMPIRF PSMCEKMRIR IVDWDRASHN
DVIGTTHLCM SKISAPGGEI DVHFNQTPVC LSGTSGSSGE GVAYRGRVLL ELTTKLTEKP
EHRAEDVPSD DLLVVEKFLR KRKFSLFVAF YSATLLQDVD DAIQFEVSIG NYGNKFDYTC
LPLASTTQFS RAVFDGCHYY YLPWGNIKPV VVLSSEWEDI RPRVEALNML LAIIDRLETN
LQQVQLEVKA GSDMEDVELR VVELLDHLIA DCSEELPALD QWQCATPLDR SLRHVRSLHL
QQITAAALAL KHGPETELSS VLEQAEDWAN RLRTIAEEPQ NSLPDIVIWM LQGDRRVAYH
RIPAHTVLFS QQYCGKHCGQ LQSVFLKYPQ GSGGEAKLPG QLRVKVWFGL AADAKHFNQF
AEGKLSVFAE TYENQTRLAL VGSWGTTGLT YPKFSDVTGR VKLPKESFRP SPGWAWAGDW
FISPERTLLF DVDAGHMTFT EEVFENQMRL PGGQWIGMPE GYTDVNGEKT VPKGEVECPP
GWAWDEVEWS EDLNRAVDDQ GWEYGITIPP DRRPKSWVPA EKMYHTNRRR RWIRMRRRDQ
QKMEALRKRP DDSDREGWEY ASLFGWNFHL KPRKTDSFRR RRWRCRMEPL EKTGPAAIFA
LECSLVKDKH DDKSVTTTFG VNRPTISCFF DRGTRYHLRC YMYQARDLLP MDKDSFSDPY
AIVSFLHQSQ RTVTVRNTLN PTWDQTLIFY EVEIFGDPDA TAASPPNIVV ELYDEDSYGA
DEFMGRCVCQ PSLAPSPRLA WFPIRRGSSG AGELLAAFEL TRREKPAVHH LPGLEVNESD
LPYPPPQREP NVFMVPQGIK PVLQRTAIEI LAWGVRNLKS FQLSSVTSPS LQVECGGSAM
QSCVIRSVKK KPNFDVNTLI LDVRLPREEL YMPPIIIKVI DNRQFGRKPV VGQCTIRSLE
EYRREMPTLT SGEVFVDIDD QEPLVPDQGE ESMDWWSKFY ASIGEKNKCG TYLEKGFDTL
KVYDQELEKV EGFEGLSDFC QTFKLYRGKT QDEGEDPSVV GEFKGMFKIY PVPDDPSAPA
PPRQFRKLPP NGIEDCVVRV YVIQAQGLQP KDANGKCDPY VKVTLGKKTI SDHENYIPCT
LDPVFGRLFE LTCSLPLEKD LRVMLYDHDM LTKDEKIGET LIDLENRFLS KYGATCGLPQ
SYCISGVNQW RDQLTPRQLL CRLCERRNLR KPVYEDEAVR FRGQRYTARH LGPVKERLSL
HILRKMGLVP EHVEVRPLYS PLQPDIEQGR LMMWVDVFPK SLGPPGPPFN VTPRKAKKFF
LRCIIWNTSD VILDDVSVSG ERMSDIYVKG WLDGHEHNKQ KTDVHYRSLG GEGNFNYRFL
FPFHYLPAEQ LCVVDRKEHF WNLDKTETKL APKLTIQIWD NDKFSFDDYL GHVAMDLNHM
LRPAKSPEKC TLQTLDQPTD KLVSLFEQKT VKGWWPCTCE SNGEKIIAGK VEMSLEIVTE
QEQEERPAGL GRDEPNMNPH LEEPQRPETS FLWFSSPYKT LRFIVWRRFK WLIVLFIILF
LIFLFLGVFL YSFPNYAAMK MVGPFGPPKA NGQ
//
