ID A0A3P9PS47_POERE Unreviewed; 742 AA.
AC A0A3P9PS47;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Golgi associated, gamma adaptin ear containing, ARF binding protein 3 {ECO:0000313|Ensembl:ENSPREP00000024595.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000024595.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000024595.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000024595.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004220}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004220}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the GGA protein family.
CC {ECO:0000256|ARBA:ARBA00008099}.
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DR RefSeq; XP_008412920.1; XM_008414698.2.
DR AlphaFoldDB; A0A3P9PS47; -.
DR STRING; 8081.ENSPREP00000024595; -.
DR Ensembl; ENSPRET00000024842.1; ENSPREP00000024595.1; ENSPREG00000016612.1.
DR GeneID; 103467933; -.
DR KEGG; pret:103467933; -.
DR CTD; 492643; -.
DR GeneTree; ENSGT00940000157333; -.
DR OMA; ECLLLWT; -.
DR OrthoDB; 2917368at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000016612; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14240; GAT_GGA3; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR044111; GAT_GGA3.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR027422; GGA1-3.
DR InterPro; IPR041198; GGA_N-GAT.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45905:SF3; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA3; 1.
DR PANTHER; PTHR45905; GOLGI-LOCALIZED, GAMMA-ADAPTIN EAR CONTAINING, ARF BINDING PROTEIN; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF18308; GGA_N-GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 15..145
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 170..297
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 613..734
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 389..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 742 AA; 79817 MW; 84FAF8BC75654DA0 CRC64;
MADDGESLES WLNKATNPSN RQEDWEYIMG FCDQINKELE GPQISVRLLA HKIQSPQEWE
AMQALTVLEA CMKNCGRRFH NEVGKFKFLN ELIKVVSPKY LGDRVSDKVK MKVIEMLYTW
TVSLPDEAKI CEAYQMLKSQ GIIVVDPEVS LNATLIPSPS PRPKNPVFDD EKKSKRLAEL
LKSKKPEDLQ EANRLIKNMV KEDEVRSQRA AKQKGTLEAV SNSVKLLNEM LAHFSPEDST
EEDKELIKEL YNDCDKLRQT VFKLATETED DDSSLGEILQ ANDDLSSAIN SYKKVVEGQS
ISGDADVAQG TETPATQGSA GTNKSEILID LVGLDTKSPS QHEPQVSSLV FSGDLLCGST
TTELQSKTAA APSAALSLLD EELLSLGLND PGPVVNESST SNQSNHLPPS QDSGQDLALF
DSSLPPAFDA LSAPSLFQQA LSTTLAPAAS TRTTTTSSAS NFPAFFTPPA ATASDLPVSV
IFPPPLGSAL SAAAPAGPSP LHSETAPAFS AGRQHVSLPG VFQPAVSSFS HNLQDLAMLD
LGGSDNHSGT STSAMTTGMQ GWSTPPALRG HPDDSPLLRS LSPIQPMSQA SPSKGDEVSL
AAVFVPLEAI RPSTLCPVTA YDKNGVRVLL HFASDCPPGR PDVLVMVASM LNTAPQSVRN
IVLQAAVPRT MKVKLQPPSG AELAPFNPIL PPAAISQVVL LANPLKEKVR MRYKLMFTLG
EQSFTEVGEV NDFPPADRWG AL
//
