ID A0A3P9PV60_POERE Unreviewed; 1144 AA.
AC A0A3P9PV60;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Zinc finger E-box-binding homeobox 2-like {ECO:0000313|Ensembl:ENSPREP00000025695.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000025695.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000025695.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000025695.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger
CC family. {ECO:0000256|ARBA:ARBA00009867}.
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DR Ensembl; ENSPRET00000025951.1; ENSPREP00000025695.1; ENSPREG00000017347.1.
DR GeneTree; ENSGT00950000183208; -.
DR OMA; MAQSPRW; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000017347; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF11; ZINC FINGER E-BOX-BINDING HOMEOBOX 2; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF05605; zf-Di19; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 197..225
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 227..249
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 268..295
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 607..667
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 957..984
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 985..1013
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 609..668
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..768
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1144 AA; 126675 MW; 4043A24831A4FD45 CRC64;
MMAQSPRWKR RKQLNPRRKS VLNYDSVLET TSETDEDDQT LLRDDSSFTG GAGDDEEVGS
PVGVPALEAS PRVGHDLLSN REPDDSEHRG EDECIDDRSS EYDAVGPEAS LQAVEDSPGR
RLDGISGLDE FFLKRKLEDD DGHQATIAEY LQRSDTAIIY PEAPEEXTRL STPEAGGQDE
SEHDLXSSAT DDFAQLLTCP YCERGYKRLT SLKEHIKYRH ENTEEAFTCL LCAETFNQRA
QLERHMITHK PTVDQPPLLS EGAANRKFKC SECGKAFKYK HHLKEHLRIH SGEKPYECSN
CKKRFSHSGS YSSHISSKKC IGLVALNGRV RNGNNSKPGS SPNSTTSXPG SPALAHLRQK
LENGRLLGLQ DQQGQVDIKT EPMDFNDYRL LMASQHGFGG PGVYLNGHSX SPLGTHGSSQ
SSFQQLGGMG IDLSLLGYAG PFGSSLSEVQ KVLQIVDNTV CRQKIDGNPE ELSKLRAYMK
ELGAQMEAQA SFQAGNSPTK SIIDYTLEKV NEAKNLINDS KMQVDVKKEK PNQSVDLSSE
EKFSDGQNPF LTFTCQYCKE TFPGPIPLHQ HERYMCKMNE DIKAVLQHPE GSPVGCRGLR
VDELSRTERP HSPTNLFKDH MSVLKAYFAM NADPNSEELL KISLAVGLPQ ELVKDWFSQW
KIQNNHMDSL RKMFQTPERG GPDRSLSRSP VSLPVIDLHN GCINTDPTHR LTKINQFTAN
KQTKGDKPLD PADPLRSNTS SPLNLSSTSS KHSQSSSYTP NSLTSEDAHG DTPLDLSLPK
HMAPKRPKPN GFITEHNGEV SVREQGSGSL GLVKIKKEFL GSDSGGSSIH QLEKSTSPIF
GINPFAGGPV YTSLPPHGAF PPPTFISPAQ ATIPGLRPYA GLDPMSFLPH MAYTYATGAA
TFAEMQQRRK YQRKAGFQGE LLDGTADYLS GLDDLTDSDS LLSRKKIKKT ESGKRPHQCQ
ICKKAFKHKH HLIEHSRLHS GEKPYQCDKC GKRFSHSGSY SQHMNHRYSY CKREAEEREA
AEREAKVGGL AGGLEPTELL MRRAYLQGLG PLGYSDPEEQ PEDGGGTILR DGREGGGQEV
GRVDNKMYEE VTDGQEASFR NREEEGDSRS QMDSMMDEGG KDSAQLMDTC SREGKTDGTL
EQED
//
