ID A0A3P9PVL5_POERE Unreviewed; 1539 AA.
AC A0A3P9PVL5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Multiple epidermal growth factor-like domains protein 6 {ECO:0000313|Ensembl:ENSPREP00000025926.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000025926.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000025926.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000025926.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSPRET00000026184.1; ENSPREP00000025926.1; ENSPREG00000017431.1.
DR GeneTree; ENSGT00940000156971; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 7.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR011489; EMI_domain.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR042635; MEGF10/SREC1/2-like.
DR PANTHER; PTHR24043:SF8; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24043; SCAVENGER RECEPTOR CLASS F; 1.
DR Pfam; PF07645; EGF_CA; 4.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00053; Laminin_EGF; 6.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 30.
DR SMART; SM00179; EGF_CA; 8.
DR SMART; SM00180; EGF_Lam; 19.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50027; EGF_LAM_2; 1.
DR PROSITE; PS51041; EMI; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Laminin EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1539
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018032691"
FT DOMAIN 28..109
FT /note="EMI"
FT /evidence="ECO:0000259|PROSITE:PS51041"
FT DOMAIN 108..143
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 186..226
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 310..350
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 568..603
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 965..995
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1008..1038
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1051..1081
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1097..1144
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1219..1254
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1348..1383
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 133..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 593..602
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 985..994
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1028..1037
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1071..1080
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1114..1123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1244..1253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1373..1382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1539 AA; 165528 MW; 5FA80CDBFA778D0A CRC64;
MFPKIFYICV KLFSAMHFAS SADLQLGMPN VCATQEVSML GVLQPCVQAL TRTVQVWKQG
CTSRRWCVGF ERRTSYYTAY RQAYSMDFHT VYKCCPGWAQ KDNEMGCLHR VCSANACLNG
GRCAETGERI CHCPLGFKGP RCQYDINECE VDEGGCEGYC CNTIGSYYCK CPDGSKVGPD
GKACIDINEC DELNGGCQQT CVNTAGSYHC ECSEGFRMHS DGRTCIAVNS CSILNGGCEH
KCVDGGDEEY KCECRRNYQL KRDGRHCELR DPCKERNGGC AQFCNSESGK ANCSCRPGFM
LSGDQKNCED IDECSSGHAK CSHGCVNMPG SFRCVCHPGF ELGAEGKQCY RIEMEIVNSC
EKNNGGCSHH CEHATNGPLC SCNQGYQLDT DRRTCVDSDE CLSVESCCSH LCRNYPGGYE
CSCRAGHRLS PDGCGCEDID ECLAETSGCE HYCVNTLGTY QCFCRMGFRL DLDWHACISL
YGGELHEEEE DEEEEEEEGL EADRLPDLLF RKAPQLVHYT AALHVRHSTD DDDDSRHVSD
LDEELKIHRE HRGELRLESS IVCLEGSFGD DCSMSCDDCV NGACSENKDR CDCSPGWTGV
ICNETCHQGS YGKSCNGMCH CLNGGSCDPV TGKCLCPLGV NGQFCEDGCP RGYFGKNCRR
KCNCPNKGPC HRLYGACLCS LGLYGRFCHL ACPKWTHGAG CSKECKCVQE QSSGCDPKTG
SCFCKPAYHG LLCEKECDPG FFGAGCEQSC DCPGGGSCDP KTGVCSQRCP AGLQGDQCQL
ACQTGNYGEN CRLTCDCGGA ACDPVTGECD CPAGKRGSSC QEDCPDGFWG LKCQLSCPFC
ENSGSCNKQT GICNCKAGSM GNLCQEACPA GHFGPGCLER CSCHPDVSCD SKNGLCICPP
GKTGHNCETT CEPGFWGQGC IGRCQCQDRS VGCDPVSGRC VCEAGHTGDH CEEKCVSGHY
GHGCAQECLC KNEALCDHVS GACICSPGFT GHLCEKTCPD GFYGLDCGQM CECRNGARCH
HITGACLCTA GWAGPHCILE CQKGRFGENC GQTCKCQNGG SCDHVTGRCS CTDGWTGAHC
QLPCSEGFFG GRCERRCDCA HSSSCHHMTG RCECQPGWRG ARCDKPCLPG FYGPSCAQRC
QCRPGVPCHH KTGSCGCPAG LTGSGCEKTC SVGSFGQNCS QLCRCSGLHE QCDAATGRCS
CSPGYYGPRC ELQCRAGSFG PNCKSKCTCV NGGRCDFRIG TCYCRPGYIG ADCSSRCPGG
HYGKDCAKLC SCAEGARCHP VTGRCICGPG RTGASCQQAC PKRRYGVQCR HTCSCQNAAA
CDPVDGFCKC GLGWTGPRCE TACPAGKYGP DCAQHCRCLN NGTCSRFTGS CSCTAGYYGD
YCQHECPSGF YGLNCQFTCD CNMGQACDHV TGKCLCPPGY YGSRCERQCE SGSFGLNCLN
SCNCADEASC DPSTGRCLCP SGQWGERCEK SCDGDHFGPD CSLLCQCFHG SHCDRVNGRC
LCPLTWLGST CSKARLHQTS GVLNMSVSHR NRRTGSKTT
//
