ID   A0A3P9PWV1_POERE        Unreviewed;       908 AA.
AC   A0A3P9PWV1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Huntingtin-interacting protein 1-related protein-like {ECO:0000313|Ensembl:ENSPREP00000026088.1};
GN   Name=HIP1R {ECO:0000313|Ensembl:ENSPREP00000026088.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000026088.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000026088.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000026088.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
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DR   AlphaFoldDB; A0A3P9PWV1; -.
DR   Ensembl; ENSPRET00000026350.1; ENSPREP00000026088.1; ENSPREG00000017426.1.
DR   GeneTree; ENSGT00940000153594; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000017426; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 6.10.250.920; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR032422; HIP1_clath-bd.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF15; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   Pfam; PF16515; HIP1_clath_bdg; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT   DOMAIN          622..874
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          192..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          870..908
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          254..288
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          362..453
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          833..869
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        880..894
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   908 AA;  101122 MW;  2EAF1487B8289D0A CRC64;
     NTAEVPPKEK YVRNIILGTH KEGGATTFWS YVPNLPLSSQ SLVSWKVCYL LHKVLREGHR
     NVTCRVTSDV PQQHKVIPGN LEASDDTLER EAGTDMTKMD ANGAKSTTLA GQCRLTPLIP
     LILDCSYLYH FSVRLLFKLH SRECLTQFFN RAREIEFFKS IIQIPDLPDG PPNFLRAAAL
     AEYKKPVVLM PGEDRPEEDE VDTQPELRET PQTSQHYLVS QMGGPEASLD YRDTDGNGYK
     RELEALKPEV ELIKSEAQKC MIELKSQVNR LEAELQEQRS HRQVALVENE HLRMEVEALR
     SANVANVGAQ IGYKEADSRA QAAEVRFTQL KERHAELVTS HADLMKKNAE TVKMLSSTKF
     VQDDLLRAKQ QLESEVENLR LEKRNAQKLE IDRLKRELDS TRAELTRANT LLQSKEMSGT
     QLSSTLAGLQ AEKDALLRSV RDQEAELSSL RQQALLHHST LEQERQRSSM ELGSLRSQMQ
     QQACREGELA QKLQDEQFCL LQCAVVEAEG IILDAVAKLD DPIHVRCISS PDYLINRAEI
     TLGSIDKMQQ SHLVYLGNRN DASGLLRAVT QFSHLAADTI VNGSATSHSA PVDHANGLTD
     SCRECANHCL QYLNDLKSQA NLQRANPSAI RYTVQRILAM GQELRPKGQD VLKEELGSMV
     DKEMVATSTA IEEAVLRMDV NTIIIDVVVF YSVQAVHILV TAATDLQKDI VEGGRGAASV
     TEFYAKNSRW TEGLISASKA VGWGATQLLD SADRVVGEKG SYEELIASSH EIAASTAQLV
     AASKVKADRN NKKLYTLQQA SRHVNDMAAV VVTSTKHGQQ QISDHGVMDF SGMSLIKLKK
     EEMEAQVKVL QLENQLDQER VRLGELRKRH YELGGPGSPD DDSFPPPPPP TLAMFSQKPN
     TASQLSKC
//