ID   A0A3P9PXT9_POERE        Unreviewed;       352 AA.
AC   A0A3P9PXT9;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000026620.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000026620.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000026620.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Ligand for members of the frizzled family of seven
CC       transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC   -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC       ECO:0000256|RuleBase:RU003500}.
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DR   RefSeq; XP_008408448.1; XM_008410226.2.
DR   AlphaFoldDB; A0A3P9PXT9; -.
DR   STRING; 8081.ENSPREP00000026620; -.
DR   Ensembl; ENSPRET00000026899.1; ENSPREP00000026620.1; ENSPREG00000018004.1.
DR   GeneID; 103465422; -.
DR   KEGG; pret:103465422; -.
DR   CTD; 54361; -.
DR   GeneTree; ENSGT00940000159654; -.
DR   OMA; YRITRDC; -.
DR   OrthoDB; 2874082at2759; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000018004; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0042074; P:cell migration involved in gastrulation; IEA:Ensembl.
DR   GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR   GO; GO:0021986; P:habenula development; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0048841; P:regulation of axon extension involved in axon guidance; IEA:Ensembl.
DR   GO; GO:0070654; P:sensory epithelium regeneration; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd19336; Wnt_Wnt4; 1.
DR   Gene3D; 3.30.2460.20; -; 1.
DR   InterPro; IPR005817; Wnt.
DR   InterPro; IPR009142; Wnt4.
DR   InterPro; IPR043158; Wnt_C.
DR   InterPro; IPR018161; Wnt_CS.
DR   PANTHER; PTHR12027:SF105; PROTEIN WNT-4A; 1.
DR   PANTHER; PTHR12027; WNT RELATED; 1.
DR   Pfam; PF00110; wnt; 1.
DR   PRINTS; PR01844; WNT4PROTEIN.
DR   PRINTS; PR01349; WNTPROTEIN.
DR   SMART; SM00097; WNT1; 1.
DR   PROSITE; PS00246; WNT1; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW   ECO:0000256|RuleBase:RU003500};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW   ECO:0000256|RuleBase:RU003500}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..352
FT                   /note="Protein Wnt"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018064099"
SQ   SEQUENCE   352 AA;  39345 MW;  E27B7DBBF3B73F4E CRC64;
     MSEDLILRCV LMLCCALLSV SASNWLYLAK LSSVGSIRDE ETCERLRGLI QRQVQICKRS
     VEVMDAVRRG AQLAIDECQF QFRNRRWNCS TLETMPVFGK VVTQGTREAA FVYAISAASV
     AFAVTRACSS GELEKCGCDH NVHGVSPEGF QWSGCSDNIA YGVAFSQSFV DVRERGKGQS
     SSRALMNLHN NEAGRKAILS HMRVECKCHG VSGSCEVKTC WKAMPPFRKV GNIIKEKFDG
     ATEVEQRKVG STKVLVPRNS QFKPHTDEDL VYLEPSPDFC DHDPRTPGML GTVGRQCNRT
     SKAIDGCELM CCGRGFQTQE VEVVDRCSCK FHWCCYVKCK QCRKMVEIHT CR
//