ID A0A3P9PXX5_POERE Unreviewed; 310 AA.
AC A0A3P9PXX5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Retina and anterior neural fold homeobox {ECO:0000313|Ensembl:ENSPREP00000026650.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000026650.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000026650.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000026650.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC initial specification of retinal cells and/or their subsequent
CC proliferation. {ECO:0000256|ARBA:ARBA00003750}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000256|ARBA:ARBA00006503}.
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DR RefSeq; XP_008422736.1; XM_008424514.2.
DR AlphaFoldDB; A0A3P9PXX5; -.
DR STRING; 8081.ENSPREP00000026650; -.
DR Ensembl; ENSPRET00000026929.1; ENSPREP00000026650.1; ENSPREG00000018023.1.
DR GeneID; 103473881; -.
DR KEGG; pret:103473881; -.
DR CTD; 30474; -.
DR GeneTree; ENSGT00940000166467; -.
DR OMA; VMMMDER; -.
DR OrthoDB; 3042435at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043562; RAX/RAX2.
DR PANTHER; PTHR46271; HOMEOBOX PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR46271:SF3; RETINAL HOMEOBOX PROTEIN RX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 114..174
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 290..303
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 116..175
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 57..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 310 AA; 34117 MW; BC2B0DA675C3C7AC CRC64;
MWLLGSTSQM MMMMMDERVS PSARSVQSPG THPSTVHSIE AILGFKEDTI FHQSASYTGT
QKDQDRSGNV TVTQGKKSHY TDSCETGVCT GEASAGPDSP DRDGKLSDDE NQKKKHRRNR
TTFTTFQLHE LERAFEKSHY PDVYSREELA LKVNLPEVRV QVWFQNRRAK WRRQEKLEVN
AIKLQDTPSP SLLSFGRSTT SSLGSGLPLE PWLSTPITSP APLQSLPGFI GGSQTLPGAY
APSPPPSMPP SLPASIFNSP ALGHSPHLSH IGSMCSLPPT YQCSANPRNS SIASLRMKAK
EHIQSIGKTW
//
