ID A0A3P9PZD9_POERE Unreviewed; 1224 AA.
AC A0A3P9PZD9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A7 {ECO:0000313|Ensembl:ENSPREP00000027134.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000027134.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000027134.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000027134.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3P9PZD9; -.
DR Ensembl; ENSPRET00000027423.1; ENSPREP00000027134.1; ENSPREG00000018341.1.
DR GeneTree; ENSGT00940000157045; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000018341; Expressed in head.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF105; SODIUM BICARBONATE COTRANSPORTER 3; 1.
DR Pfam; PF07565; Band_3_cyto; 2.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 592..614
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 621..640
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 679..702
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 709..727
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 808..826
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 846..864
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 894..913
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 934..958
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 994..1013
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1020..1039
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1078..1102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 145..258
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 369..514
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 563..1072
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 57..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1127..1165
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 57..72
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 137290 MW; F1FA6DCFACEF4422 CRC64;
MDESREQMNP LLSRGLDEEA LVDHGKTSFT TLSNYETEDL ESHRAVYVGV HVPFGRGSKR
RHRHRERRHH RKKKDRDCEE EKEDGRESPS YDTPSQRVQF ILGTEDDDLE HIPHDLFTEL
DELSFRDGGA TEWRETARWL KFEEDVEDGG ERWSKPYVAT LSLHSLFELR SCILNGTVML
DMRANSIEEI ADMVIDSMVA SGQLKEDLRA KVREAMLKKH HHQNERKLSN RIPLVRSIAD
IGEGLSSSRL SLHKPGLASS VSSLSQRRES RVSVLLSHLL PSSSSNTGLS PGPSPHSTPQ
NTPLSFRRSH LSPSQTRCTG PGPQGIPEVV VSPPEDDEPA NSAEEDAVSP QLTRRTSSAS
QNHELLPLEG PMVSPHSLPN NLDGNKAMER RPSKVGVDMN FMKKIPPGAE ASNVLVGEVD
FLEKPIIAFV RLSPAVLITG LTEVPVPTRF LFLLLGPHGK GPQYHEIGRS MATLMTDEIF
HDVAYKAKDR TDLLSGIDEF LDQVTVLPPG EWDPTIRIEP PKNVPSQMKR KRPSHPNGNA
PPAGELEKED DHHAGPELQR TGRIFGGLIL DVKRKAPFYW SDIKDSLNLQ CLASILFLYC
ACMSPVITFG GLLGEATKGS ISAIESLFGA SLTGVAYSLF AGQPLTILGS TGPVLVFEKI
LFKFCKDYGL SYLSLRTSIG LWTAFLCILL VATDASSLVC YITRFTEEAF AALICIIFIY
EALEKLFHLG EYYPVNMHNN LDNLTFYSCQ CSPPANASDQ LLQHWNRTGY NSSDSIPWSN
LNVSMCKLLD GEFVGPACGH HGPYIPDVLF WSIILFFTTF FLSSFLKQFK TERYFPTKVR
STISDFAVFL TIMIMVLVDY LMGIPSPKLH VPDRFEPTSK HRGWLMDPLG ENPWWTLLVA
AVPALLCTIL IFMDQQITAV IINRKEHKLK KGCGYHLDLL IVAIMLGVCS IMGLPWFVAA
TVLSISHVNS LKVESGCSAP GEQPKFLGIR EQRVTGFMIF TMMGCSVFMT SVLKFIPMPV
LYGVFLYMGV SSLKGIQFFD RIRLFGMPAK HQPDLIYLRY VPLWKVHVFT LVQLTCLVLL
WVIKASAAAV VFPMMVLALV FIRKLLDLLF TKRELSWLDD LMPESKKKTE DDKKKKAQEK
LHCLLKEEES QLEEEEEEER KMKVHFEGSN RLNIPVNSIS GRSYRIGVVT ESLQWKNSQE
KVACVRVDVS PDSPGEGSTA ETFL
//
