ID A0A3P9Q0P2_POERE Unreviewed; 914 AA.
AC A0A3P9Q0P2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Low density lipoprotein receptor-related protein 6 {ECO:0000313|Ensembl:ENSPREP00000027584.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000027584.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000027584.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000027584.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A3P9Q0P2; -.
DR STRING; 8081.ENSPREP00000027584; -.
DR Ensembl; ENSPRET00000027884.1; ENSPREP00000027584.1; ENSPREG00000018643.1.
DR GeneTree; ENSGT00940000158990; -.
DR OMA; NPERYMY; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000018643; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF13; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 4-LIKE PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 36..78
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 160..202
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 209..246
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REPEAT 293..335
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 378..422
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 423..464
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 514..552
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT REGION 759..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 577..592
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 595..607
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 602..620
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 630..642
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 637..655
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 649..664
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 914 AA; 101417 MW; 09DA8A8BC4FA2E45 CRC64;
VLQTISRAFM NGSALEHVVQ FGLDYPEGMA VDWLGKNLYW ADTGTNRIEV AKLDGQHRQV
LVWKDLDSPR ALALDPAEYM YWTEWGGKPK IDRAAMDGTG RITLVSNVGR ANGLTIDYAE
RRLYWADLDT TLIESSNMLK EREVIADDLP HPFGLTQYQD YIYWTDWSHR SIERANKTSG
QNRTLIQGHL DYVMDILVFH SSRQAGWNAC ASTNGHCSHL CLAVPSGFVC GCPAHFSLNR
DNKTCSAPTA FLLFSQKAAI NRMVIDEQQS PDIVLPIQNL KNVRAIDYDP LDKQLYWIDS
KQNVIRRAQE DGNQTVTVVS SSLLGPFDLS IDIFSRFIYW TSEVTNVINV TRTDGSRVGV
VLRGEHDKPR AIVVNPERYM YFTNLQDRSP KIERAALDGT EREVLFFSNL GKPVALAVDN
EAGKLFWVDS DLRRIESSDL SANRIVIADS NILQPVGLTV FGNHLYWIDK QQQMIERIDK
TTREDRTKVQ ARVAYMSDIH AVHEIDMHEY GNHPCTRDNG GCSHICIVKG DGTTRCSCPV
HLVLLSDELT CGPPTCSPDQ FACVSGEVDC IPNTWRCDGF AECDDHSDEK ECPVCSESEF
QCDSRQCVGQ SERCNGEVNC QDGSDENKRC PADQFSCANS QCIGIHKKCD HNTDCSDNSD
EMDCDPPELP APTNSTISSI VAVVMALFVV GAIYFVCQRV LCPHMKDDGE TVANDFVVHG
QASVPLGYVP HPGSLSSSLP MSRGKSVIGS LSIMGGSSGP PYDRAHVTGA SSSSSSSTKG
TYFPPILNPP PSPATVRSQY TLEFGYSSNS PSTHRSYSYR PYTYRHFAPP TTPCSTDVCD
SDYTPGRRPL KSAAKGYTSD LNYDSEPFPP PPTPRSQYLS AEENCESCPP SPYTERSYSH
HLYPPPPSPC TDSS
//
