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Database: UniProt
Entry: A0A3P9Q1H0_POERE
LinkDB: A0A3P9Q1H0_POERE
Original site: A0A3P9Q1H0_POERE 
ID   A0A3P9Q1H0_POERE        Unreviewed;      1120 AA.
AC   A0A3P9Q1H0;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN   Name=MAN2A2 {ECO:0000313|Ensembl:ENSPREP00000027910.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000027910.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000027910.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000027910.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361199};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR   STRING; 8081.ENSPREP00000027910; -.
DR   Ensembl; ENSPRET00000028217.1; ENSPREP00000027910.1; ENSPREG00000018857.1.
DR   GeneTree; ENSGT01030000234638; -.
DR   OMA; GEMEIMQ; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000018857; Expressed in caudal fin and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF57; ALPHA-MANNOSIDASE 2X; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361199};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361199};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT   TRANSMEM        7..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          475..561
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1120 AA;  127275 MW;  34B4D8F0436A059A CRC64;
     MKLRKQVTVC GGAIFCVAVF SLYLMLDRVQ HDPARRQNGG NFPRSQISVL QNRIEQLEQL
     LEENHQIISH IKDSVMELTD TGAVSPSGHL PFRSANGSWV LPFDGRPTFL ALKPQDCQFT
     VGTRAQTDVQ VNVPLFKIRS ICVSLGPPVL LGWVKTFDKY FTDQTQHILN NMVVKLAEDS
     RRKFIWSEIS FFAKWWETAD VYKQEAMRKL ILGGQLEMVT GGWVMTDEAN SHYFAMIDQL
     IEGHQWLERN LGITPQSGWA VDPFGHSATM PYLLKRANVT SMLIQRIHYS IKKHFSSTRS
     LEFMWRQAWD TGSSTDIFCH MMPFYSYDVP HTCGPDPKIC CQFDFKRLPG GRINCPWKVP
     PKSVVEANVA ERAQLLLDQY RKKSKLYRSK VLLVPLGDDF RYDKAQEWDQ QYINYQKLFD
     YMNSHPELHV QAQFGTLTEY FTALYKAYGV PQGSRPGDFP VLSGDFFAYA DREDHYWTGY
     YTSRPFYKSL DRVIESHLRG AEILYSLAVA NARHAGMEGR YPVTDYALLV DARRSVGLFQ
     HHDAIAGTAK ENVALDYGTK LLRALIGLKR VIINAAHFLV MKNKEFYRFY QTEPFLETDD
     RRATQDSLPQ RTLIELDPAR PRYLVLFNPI EQERLCTVTV LVNTVRVRVL TEDGQTLPVQ
     LSAQWSSATQ MSATFMVRLP PLGLAVFHLY DSADSPMTIR SDTLLRLSGR SVSARALDPL
     PVRSQPADAQ TFYISTQTLT LGFSGTTGLL ESIKCKDDPQ EIKVQMQFMI YGTSPSKDKS
     GAYLFLPDGK PKPYNQKEPP AVRVVEGPLF SEVVAQYQHF QQTVRIHNVP GVYGLSVDIT
     ILVDIRDQTN KELSMRLVTS IQNGDVFYTD LNGYQIQPRR FYQKLPLQGN FYPMSSQAYI
     QDSHHRLTLH TAQALGVSSL DSGQLEVIMD RRLMQDDNRG LGQGLKDNKK TANRFRLLLE
     RRSIDNKMMD SATTSFPSMV SHXTSSLLNH EVLALPVLPK RRGIPPLQTF APLKTVIPCD
     VHLLNLRSIQ TQKDPESPSP YTALLLHRLA INCGFEGQNL GFNCSTTQGR LSVSNLFKNV
     DLQLLQPMSL TLMHSSKPLA NDSIISLEPM EISAFKLKLH
//
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