ID   A0A3P9Q1W1_POERE        Unreviewed;       703 AA.
AC   A0A3P9Q1W1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=TANK binding kinase 1 {ECO:0000313|Ensembl:ENSPREP00000027853.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000027853.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000027853.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000027853.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P9Q1W1; -.
DR   STRING; 8081.ENSPREP00000027853; -.
DR   Ensembl; ENSPRET00000028159.1; ENSPREP00000027853.1; ENSPREG00000018704.1.
DR   GeneTree; ENSGT00950000182937; -.
DR   OMA; WSADMPV; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000018704; Expressed in head and 1 other cell type or tissue.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR   CDD; cd13988; STKc_TBK1; 1.
DR   Gene3D; 1.20.1270.420; -; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR041309; TBK1_CCD1.
DR   InterPro; IPR041087; TBK1_ULD.
DR   PANTHER; PTHR22969; IKB KINASE; 1.
DR   PANTHER; PTHR22969:SF14; SERINE_THREONINE-PROTEIN KINASE TBK1; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF18394; TBK1_CCD1; 1.
DR   Pfam; PF18396; TBK1_ULD; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          9..310
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         38
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   703 AA;  80781 MW;  1358AEE5BBB7D6BF CRC64;
     MQSTANYLWL ISDLLGQGAT ANVYRGRHKK TGDLYAVKVF NNLSFLRPLD VQMREFEVLK
     KLNHKNIVKL FAVEEETNTR HKVLVMEYCP CGSLYTVLEE STNAYGLPED EFLIVLHDVA
     GMNHLREYGI VHRDIKPGNI MRVIGEDGCS VYKLTDFGAA RELEDDEQFQ SLYGTEEYLQ
     HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVRYKIITE
     KPSGTISGHQ KSENGKIEWS TEMPVSCSLS RGLQSLLTPV LANILEADQE KCWGFDQFFA
     ETNDILHRAV VYVFSLQQAT LHHVYIHEYN AALFQDLLCR RTSIPLHNQE LLYEGRRLVL
     DSNRQAKTFP KTSRDNPIMV VSREVVATVG LIFEDSPPKV QPRYDLDLDA SYAKLQTFAG
     DVGHLWKTSE SLLVYQELVR KGVRGLELMK EDYNEILHKK SEVFRLCSIC TQQLEKAEHL
     EVLMQANMLT SEYEDIADMH KKALRQISSS LDPIERTTQD VKSKILPGGV LTDSWTLQVG
     THPEDRVEKI KVLLDAITAI YQQFKKDKAE RLPYNEEQIH KFDRQKLVIH AGKARSLFTD
     ECAMKYRLFI SKSEEWMKVH HVRKQLLGLS GQLIGVEKEV TVLLDRAAKL QEQLPQKVLV
     PNVMKAQSYL SPNTLVEMTL MKKLKEEMEG VVKELAENNH FLE
//