ID A0A3P9Q270_POERE Unreviewed; 1604 AA.
AC A0A3P9Q270;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSPREP00000028242.1};
GN Name=ARAP1 {ECO:0000313|Ensembl:ENSPREP00000028242.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000028242.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000028242.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000028242.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_008423680.1; XM_008425458.2.
DR RefSeq; XP_008423681.1; XM_008425459.2.
DR RefSeq; XP_017163805.1; XM_017308316.1.
DR Ensembl; ENSPRET00000028555.1; ENSPREP00000028242.1; ENSPREG00000019122.1.
DR Ensembl; ENSPRET00000028581.1; ENSPREP00000028269.1; ENSPREG00000019122.1.
DR Ensembl; ENSPRET00000028625.1; ENSPREP00000028313.1; ENSPREG00000019122.1.
DR GeneID; 103474463; -.
DR KEGG; pret:103474463; -.
DR CTD; 116985; -.
DR GeneTree; ENSGT00940000157424; -.
DR OMA; QTELREW; -.
DR OrthoDB; 4835at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000019122; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08837; ArfGap_ARAP; 1.
DR CDD; cd13259; PH5_ARAP; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 3.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 4.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 5..69
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 493..585
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 600..689
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 695..822
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 903..1010
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1120..1296
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1332..1419
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1432..1546
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 77..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..221
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..334
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1604 AA; 180933 MW; 4A63F3D74DC8A379 CRC64;
MSLTESSANV SDWLSMLRLE QYGEAFQEAG LTKLQDCQNL TPDQLDRMGI NLPGHQKRIL
ANLNKMTASY VAHANVVKPE SSEQTGRPEV KRKEKPVPVP LQKKVEEGKM DGEITRPTPR
ERDKPVPKER HLCNTQDNSN GEGKPKPVPV QRHSAPVGGK EEERSGAPDG KRAKPVPKER
TKFRSNSSVN CHPTPIVSAL PDASLPPVPP RSTPNCPPQP FVSSPAQHSG SLSLDRIVVV
PPPEVKCRSS SQKSTPTSTF VSTEAPIQTP SIQSSTPRSN SLPIQPSTHS FGEDEARKAS
PVSSASSAIE DKSVPPLPPK AGFKGPPPIP QRVPLQSPKT HSPPLTKKGT EELIQTDPTP
QVPLRNRTPQ AQEISKPSEQ TELQPALPAR KISKPPLLVP VDDSSNDYID TDLLNSSVQQ
RKVTDRDMSL QVPIHHQKRV YSLCSDDELL DEDDPDFPPW QTERIANLPG SFCLPDSGRL
STPVKEDSSQ LSSVIKMGWL DKNPPQGALY YQRRWVKLEV DYLKYFDNEK EVYSKGFIST
AFITNVSSVG ELKFEVATNN RTFIFRAENE DERNEWVTLL RDCTGGPKRP ISLIAGSPLT
PDYFGYLELR GLRSKLFTVV ASDKVLLYKN ADDYRIGVGI TFIDMNVGNV KDSDRRSFDL
TTPYRIFSFI AESEQSREQW VQAMRNAIGE ALSNSEVIEQ FWTEPSNSLC ADCGAPKPDW
AAINLCVVIC KQCAGEHRGL GPSISKVRSL KMDKKIWTEE LIQVFLKLGN ERVNSFWAAN
VPPSEALSPS SCSEDRRRFI SNKYRQGKYR KYHALYGNQK ELNNALCINV QCSDLLETLS
LIFCGADVNC STGMANCPSP ESLASAHSQP LQAELIKHNL NTELPQLQTE PDMDLKHYPP
PPCVSYDGYL FKTASMGRAV AERKMKEEFS RRWCMLNDGT FSYYEHDKST NPNGTLKASE
IVCLAVDVPE KHGYEFTFEL YSESERIYLF GTDEPDTYKE WVKCIAKTFI PATAEPLLRL
SFERIGRLKC KDGLNLQKSK VGWFALAGST LHVYLENSKG EEIHLRKLNE LSIQQDNEVL
VLVEKGRTLY IEGERKLDFA GWCGAIQAAA GSGGDTLSQQ QLTDTDIPVI VLSCIDYITQ
CGMTSEGIYR KSGVNSRVTA LCDRFRRDAR SLRLKEGEHQ VDDVSNTLKR FFRELEEGLF
TSEYAYSWLS ITALPDENDK ISEYKALLDR LPCVNKATLQ ALINHLYCVQ RFSDLNQMNL
HNLAIVFGPT LFQTDGKDYT AGRAIEDLIQ HYILIFEVDE QQLDKQLKEI KAIIDMTDLR
IRPKFPKPGG NGHFICTVYL EELKDTAEQH VKIPGSMTAA ELVYEVLDRR NIPVRDKDYW
SCWEVCEEIE RPLHYQERVL PILHSAGNES HLLIKKQPAM DAMVNYLATK VDVSKHGMMK
FREERSILGL GLPSGNFHDR FFILNVTSLR MYKDVRSHRA EREWVVKNLK IYLGIKKKLR
PPTCWGLTVV YESKKQEKPE RQQWYLCCET QSEMREWYAT FLSIQNDGNL WPQDGVQQNR
VSRALPDTRH GNVSLIPLRG SENEMRNSVA AFSQDALALL RDVR
//
