ID A0A3P9Q2P4_POERE Unreviewed; 363 AA.
AC A0A3P9Q2P4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Homer scaffold protein 1 {ECO:0000313|Ensembl:ENSPREP00000028345.1};
GN Name=HOMER1 {ECO:0000313|Ensembl:ENSPREP00000028345.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000028345.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000028345.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000028345.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the Homer family.
CC {ECO:0000256|ARBA:ARBA00023606}.
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DR AlphaFoldDB; A0A3P9Q2P4; -.
DR Ensembl; ENSPRET00000028657.1; ENSPREP00000028345.1; ENSPREG00000019187.1.
DR GeneTree; ENSGT00940000156354; -.
DR OMA; QXSAISK; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000019187; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR CDD; cd01206; EVH1_Homer_Vesl; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR044100; Homer_EVH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF3; HOMER PROTEIN HOMOLOG 1; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..363
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018052474"
FT DOMAIN 5..117
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 122..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 189..334
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 129..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 363 AA; 40950 MW; 439E4A391EA0882C CRC64;
MLLLLFLCSE QPIFSTRAHV FQIDPSTKKN WVPTSKHAVT VSYFFDSTRN VYRIISLDGS
KAIINSTITP NMTFTKTSQK FGQWADSRAN TVYGLGFSSE SHLSKFAEKF AEFKEAARLA
KEKSQEKTEL SSTPSQESAP GDLQSPLTPE SINGTDEDRV TPNTPKHSEA RAEPPQNALP
FSHSSSSINK HWEAELAALK GNNAKLTAAL LESTANVKQW KQQLAAYQEE AERLHKRVTE
LECVSGQTTV NKSQKTELNR TIEELEAALR AKEEELERLK EEVESANEFK FQKDSLTQKL
KETESRNQTL EAQLSDLEQR LESSQLEREA YMKSLRSLLE LLDSKIFELT ELRDTLAKLV
EGS
//
