ID A0A3P9Q3W2_POERE Unreviewed; 866 AA.
AC A0A3P9Q3W2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase N2-like {ECO:0000313|Ensembl:ENSPREP00000028699.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000028699.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000028699.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000028699.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_008432977.2; XM_008434755.2.
DR AlphaFoldDB; A0A3P9Q3W2; -.
DR STRING; 8081.ENSPREP00000028699; -.
DR Ensembl; ENSPRET00000029015.1; ENSPREP00000028699.1; ENSPREG00000019425.1.
DR GeneID; 103480019; -.
DR KEGG; pret:103480019; -.
DR GeneTree; ENSGT00940000154095; -.
DR OMA; ENVQSHT; -.
DR OrthoDB; 2911650at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000019425; Expressed in head.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR029403; RESP18_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF14948; RESP18; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..866
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018303517"
FT TRANSMEM 602..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 733..866
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT REGION 114..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 866 AA; 95276 MW; 0BAA2F890E210229 CRC64;
MDSLPSSFLL FLLLLLITSP LCSPAAADRR IGCLFENELC SSYEICVNDG MFGRCHSVPV
RDVYAYDVSP SVVQRFRILL EKLSNRGLTW EDDTTQKVLS SELSKLRRIP YRPQQKGPIY
SSSSRPAAEA MDPEDQRVKP VEVELNRNLQ TYLQRLGLLP KTSSASSLSK PGKPLQKQKQ
KQKPLSSQLL ASQADGDLLL AALRRFLSGR LSLLGAGMKQ EAASPRLRPF YSSSVENPGF
MKETPQSRLV KTGSSPAASA KEPLTSVDER FIEKVMKNVG RQHVDVDSLT PQDLSQLSSL
IADALLVVDQ DQGPARPLSR DRGPGLRDLE GERSDSSQEA SRAEEVLLQN VPTLNPDPQG
RSAQLPLAAL QERHTDAVDD PAQSSSLFNK LLAYLDKASL SDPSSVRSRY DVAAAAPRGR
QVGLENVQSH TSEAGVAVQK KDTTQSVEEV SEVAGWIKEV VPPPASLVYK EPHKKTMHAP
ELQLDVKTDR KKPDDDVFGY VITDTDRLQT DDGLHLMEIL AHRSNIQMTD FTELVVVGPA
VTFKVSRNSQ NVSTADVANV AVKQKADLEK ETKLTILEAG VADESQIKQI PTKYSQGEST
KFLILTIVSI LCIVGVLLAS TVVYCLRHRS HHKLKEKLTN LGTDSGGDAT ATYQELCRQR
MSVKPSVDRP EPISSRINSV SSQFSDGGPA ISPSGRGSIS SWSEEPAHSN MDISTGHMIL
SYMEDHLKNK DRLAKEWEAL CAYQAEPNAT ATGLKNGNAK KNRSTAVVAY DHSRITLKVE
NSQANSDYIN ASPVMDHDPR NPAYIATQGP LPSTVADFWQ MVWENGCVVI VMLTPLVENG
VKQCYHYWPD EGSNLYHIYE VKVALL
//
