ID A0A3P9Q7B7_POERE Unreviewed; 1001 AA.
AC A0A3P9Q7B7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Integrin subunit alpha 8 {ECO:0000313|Ensembl:ENSPREP00000029960.1};
GN Name=ITGA8 {ECO:0000313|Ensembl:ENSPREP00000029960.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000029960.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000029960.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000029960.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3P9Q7B7; -.
DR Ensembl; ENSPRET00000030302.1; ENSPREP00000029960.1; ENSPREG00000019979.1.
DR GeneTree; ENSGT00940000156737; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000019979; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF5; INTEGRIN ALPHA-8; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 947..971
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 33..100
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 116..177
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 293..358
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 359..417
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 424..486
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 502..590
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 606..723
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 728..938
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1001 AA; 109664 MW; 493116DCAFDEA03A CRC64;
MERVWDCASS AGMFMLGVLS VLWPAPNRVW SFNLYAEHPT VYSGPDGSYF GYSVDFYQAS
TERNTISVLV GAPKANTSQP GIVEAGAVYY CPWPGQSDSC RQIPFDNSNN RMIKVNGTRE
PLEFKSHQWF GASVRTHKGK VVACAPLYHW RTVKRDGEKD PVGTCYVAVQ NFSAYAEYSP
CRTNDPDPEG QGFCQAGFSV DFTKVKTGRI AGQVMTAGIA EILNGYSLKA VLRRVPGEKQ
TGAAEDTNDD SYLGYSVAVG EFTGDSEQEL ITGVPRGAQN FGYVAMINST NLTFIQNFTG
EQMASYFGYS VAVTDLNGDD TDDILVGAPL YMEREMESKP REVGRVYLYL QLAPLRFSEP
IVLSGTYTFG RFGTAIAPLG DVNQDGYNDV AVGCPFGGED RGGRVLIFNG NRDASARGLT
LSQELRASRT PGGGLPGYGF TLRGGQDLDG NEYPDLIVGA FGAGEVSVYR SRAVVSVEAT
MSLTPVIRDL NPSSSVAIIC SDLKAELHLD WLKGTRGGVK RVLFLDTQQA QHSGLVRLGQ
SLHIIFNSVA SQEEDEFRDK LTPIALALNY SLAPPSSDKT LPPILNHYLK HFPITSSSQA
YILLDCGDDN ICIPDLQLSA KLVIGDDNLI MLTITAANRG EGAYESELHT LIPPEADYIG
VERRLNCEYK TINESRMVVC DLGNPMVTGT EVSFLLIVLV IFPYSSNKDN SESNMVSLNL
TVAAKAQLDL RGVSHPSQVV LPFPNWEPKK KPVKEDDVGP QVTHIYELHN AGPSSIGQAE
LQVGWPARFR DENLLYAMEI QTDGPISCRT NSSLNPQGLQ ISSLQDTPEL LGFLRNTTDP
PHRHKRSVGT AESYSSKTLN CTNISCLRIT CVVGRLDRGQ SAVLKIRSRL WAHTFLQRRN
DPYVLNSTVS FMVISVPYRI QPPALPQHRI SMGTLVLWGT PDVSFAVPLW VIILAILLGL
LVLAMLTLAM WKCGFFDRAR LPADDDVSDQ EKLTSDQTGD A
//
