ID A0A3P9Q7T5_POERE Unreviewed; 1089 AA.
AC A0A3P9Q7T5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Integrin alpha-3-like {ECO:0000313|Ensembl:ENSPREP00000029873.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000029873.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000029873.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000029873.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3P9Q7T5; -.
DR STRING; 8081.ENSPREP00000029873; -.
DR Ensembl; ENSPRET00000030214.1; ENSPREP00000029873.1; ENSPREG00000020187.1.
DR GeneTree; ENSGT00940000157746; -.
DR OMA; RYNHTGA; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000020187; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0033334; P:fin morphogenesis; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0060297; P:regulation of sarcomere organization; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 28..1089
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5017846067"
FT TRANSMEM 993..1017
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1038..1065
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 33..98
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 288..349
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 350..405
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 409..471
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 456..605
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 607..757
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 772..968
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1089 AA; 120889 MW; 5F7CA4D925A84ABE CRC64;
MRNLNMFLRL ILWTALAAYR GTPTCDGFNI DAKFPVIKQG KTDGSFFGFS VALHRQTKGS
DKYLLLVGAP KEKANSLPNV NETGAVYACP ISEDRTDCTR MDLVTSTKPS EIVEGMWLGV
TVATQRSLKE GRVLACGHRY VKISTGQRRM IGKCFVRSND LTLDNNDLWQ TDSYERCNPG
DDHKKEGMCN LGISGGITET DVVLGATGSN NWKGNVHLTW RDPNPDNYGT SIQRTIKDDK
KNNIYIGYSV LEEQKLLSSH HNTVVTGSPR DESKGSVMLG EQIQDKIQIT HTILGEQVGS
YFGSSLAATD LNNDGWNDLI VGAPFYFDRN ALSGGAVYVF MNENGSFQST CTMKLTGEAF
SGFGTAVAAI GDVNQDGFQD FAVGAPFHGT GRLYIWMGSK TGVSQQPSQI IEGTSVVNGN
FQTFGYSINA GMDTDNNGYP DILVGSLDER VALLRARPVI HLTIDFTAEP KIVDPKNCPA
ANPCISVKAC LSFTLSNGNK NFKKNINIPC EVEADTLFSK KPRVQFQNGV NKFTITLTQP
SSSPVCRVLK LSVEDRVKDK LEPVVFSLNV TLPEHDGNPR SIEDLFPTKS PEQKLTQRTE
INFQKACGVD NKCTSNLQLS AEFAHDNGTL VPRKKLVQVL QFDKSLKRIK LLVVVTNFDS
SGKAAEDAHL AMLNVSIPNA IQYSGVRSDN PDVECRFDVT VMCELGNPLK AKEKVSLQLL
FETSGIDLYT TAIEIQLMLS TLSEQSDLRP ATAALQIESI IKPSFFPEDF EEKTKFGGTV
KGEYAMHNTS DAGSLVEFTL NVNMHDEPLG DMGILAVEFD WPFEVPNGKW LLYLTKIVVN
GESEMDCIPA GVINPLNLTL SESRPSQARS KRQTDENDME EKIQLHVVEP QAAITLHPSR
KSYVLDCSVG TARCVKFTCP LLNMSRTAKI RVRSRLWNST MLEDYPNALN VRVKVRATLK
LITDKPTIKM DTIDLPLTVY IEPEESVEIP YELPLWIIIS AAVAGLLLLG IIILIMWKVR
RLWVLNDTLQ SSMLCYVMLC YVMLCYVMLC YVMLCYDTIV VAYLFQKGQS TSHNIPDCYL
FIFFSYLHQ
//
