ID   A0A3P9Q822_POERE        Unreviewed;       800 AA.
AC   A0A3P9Q822;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Cysteine rich transmembrane BMP regulator 1 {ECO:0008006|Google:ProtNLM};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000030322.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000030322.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000030322.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3P9Q822; -.
DR   STRING; 8081.ENSPREP00000030322; -.
DR   Ensembl; ENSPRET00000030666.1; ENSPREP00000030322.1; ENSPREG00000020473.1.
DR   GeneTree; ENSGT00940000164910; -.
DR   OMA; THGYCAL; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000020473; Expressed in head and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 6.20.200.20; -; 5.
DR   InterPro; IPR004094; Antistasin-like.
DR   InterPro; IPR045813; CRIM1_C.
DR   InterPro; IPR011061; Hirudin/antistatin.
DR   InterPro; IPR001007; VWF_dom.
DR   PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR   PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR   Pfam; PF02822; Antistasin; 4.
DR   Pfam; PF19442; CRIM1_C; 1.
DR   Pfam; PF00093; VWC; 4.
DR   SMART; SM00214; VWC; 5.
DR   SMART; SM00215; VWC_out; 4.
DR   SUPFAM; SSF57603; FnI-like domain; 5.
DR   SUPFAM; SSF57262; Leech antihemostatic proteins; 2.
DR   PROSITE; PS51252; ANTISTASIN; 4.
DR   PROSITE; PS01208; VWFC_1; 5.
DR   PROSITE; PS50184; VWFC_2; 5.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        697..718
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          170..226
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          239..295
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          307..336
FT                   /note="Antistasin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51252"
FT   DOMAIN          342..369
FT                   /note="Antistasin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51252"
FT   DOMAIN          376..401
FT                   /note="Antistasin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51252"
FT   DOMAIN          404..429
FT                   /note="Antistasin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51252"
FT   DOMAIN          447..504
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          518..576
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
FT   DOMAIN          592..650
FT                   /note="VWFC"
FT                   /evidence="ECO:0000259|PROSITE:PS50184"
SQ   SEQUENCE   800 AA;  87669 MW;  AAEB7D4B66DE9FB1 CRC64;
     MVLCPPPPGV PRRCRSLEQT GDLTAPLTES YFFGCFLPEH PDAGLEDERC PLITGCDKAG
     AECVCDARYS CLGTFTYPDQ ETCMKASKSG AVGSECAGVT CPALQLPSCP KGSVLTKSYT
     PPAGCCPSMP PQCTCDFRAC NKTHCPSGQH AVLISQASGR PGDCCDVFEC QKGNSTEFSE
     GEVYRMDPCW LCQCRGGISF CSKAECGELD CEKFYIPEGE CCPVCIGTHT QAILSLKCAS
     CWVNNKLRTH EEQWKEDDCT FCQCVDGDPH CTAMACKQSC QNPVKIPGEC CPFCEEPSYE
     TVSPLLCPPL ENCSLSGNEC PYGFQQDHNG CLLCQCLNND SCPDLGKYCP LQCPTGYEKD
     DLGCEVCECS ILTPKCRTLT CTKTCPYGYV RNKHGCEMCR CVKCPPFTCD KYCSNGYRQN
     RKGCNICTCH IDAGSHFITT VPASMPSFCL TSNGRRYEEG DSWHDGCRDC YCLSGREMCV
     LISCPMPSCS QPVVKSGQCC PTCEDESGSG QPEGMDMVVC RAPGGELYVE GETWNLNECM
     RCTCRKGRVL CDIEVCPPAL CQTPVRNKDT CCHMCPEETE SNLLPVNGSQ QEFCITAEGD
     MLQAGDSWKA NACTSCTCNN GTIQCFSQHC PAASCRVPVL LKGQCCPHCL GTFLGGCREK
     HRQEKAAFCS GKLSLVETVF RLNYPSHTEM ALVYQSAAWI LAGLLLAIII FLIVALLINK
     KKKWVQMSCY SAPKKTVILK KHVNKNSVIY MEPSKENKFQ NMKSDCGIIH FSPEMSSPPC
     TEKMTIPRAK LSMGSDWTPR
//