ID A0A3P9Q8K5_POERE Unreviewed; 887 AA.
AC A0A3P9Q8K5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Extracellular calcium-sensing receptor {ECO:0000256|ARBA:ARBA00039746};
GN Name=CASR {ECO:0000313|Ensembl:ENSPREP00000030502.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000030502.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000030502.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000030502.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3P9Q8K5; -.
DR Ensembl; ENSPRET00000030846.1; ENSPREP00000030502.1; ENSPREG00000020592.1.
DR GeneTree; ENSGT00940000157596; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF358; EXTRACELLULAR CALCIUM-SENSING RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..887
FT /note="Extracellular calcium-sensing receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018013358"
FT TRANSMEM 597..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 667..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 710..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 788..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 597..847
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 887 AA; 100662 MW; 5FCEFF982464B172 CRC64;
MRLFLCYLIV LGSNYVISTY GPHQRAQMTG DILLGGLFPM HFGVASKDQD LAARPESTQC
VRFNFRGFRW LQAMIFAIEE INNSSILLPN ITLGYRIFDT CNTVSKALEA TLSFVAQNKI
DSLNLDEFCN CTDHIPSTIA VVGAAGSAVS TAVANLLGLF YIPQISYASS SRLLSNKNQY
KSFMRTIPTD EYQATAMADI IEYFQWNWVI AVASDDDYGR PGIEKFEKEM EERDICIHLN
ELISQYFEDY EIRALADRIE NSTAKVIVVF AGGPDIEPLI KEMVRRNITD RTWLASEAWA
SSSLIAKPEY LDVVGGTIGF ALRAGLIPGF REFLQQVQPK KDSHNEFVRE FWEETFNCYL
EHSPRLQESE NGSTSFRPLC TGEEDITSVE TPYLDYTHLR ISYNAYVAVY SIAQALQDIF
TCTPGRGLFA NNSCADIRKI EAWQVLKQLR HLNYTNSMGE KMHFDENADL VANYTIINWQ
RSTEDGSVMF KEVGYYNIHA KKGGKLSIDK TKILWNGCDS EVPFSNCSED CEPGTRKGII
DSMPTCCFEC TDCSDGEYSN HRDASVCTKC PNNSWSNGNH TFCFLKEIEF LSWTEPFGIA
LAICAVVGVV LTTFVMGVFI RFRNTPIVKA TNRELSYVLL FSLICCFSSS LVFIGEPQDW
TCRLRQPAFG ISFVLCISCI LVKTNRVLLV FEAKIPTSLH RKWWGLNLQF LLVFLCTFVQ
VMICVVWLYN APPSSYRNYD IDEIIFITCN EGSVMALGFL IGYTCLLAAI CFFFAFKSRK
LPENFTEAKF ITFSMLIFFI VWISFIPAYF STYGKFVSAV EVIAILASSF GQLACIFFNK
VYIILLNHYP QSILLGFCVT DHHKVANNYE KHLFFYVVWI LMKAPLL
//
