ID A0A3P9Q984_POERE Unreviewed; 154 AA.
AC A0A3P9Q984;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Endothelin-3 {ECO:0000256|ARBA:ARBA00040198};
DE AltName: Full=Preproendothelin-3 {ECO:0000256|ARBA:ARBA00041850};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000030717.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000030717.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000030717.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides.
CC {ECO:0000256|ARBA:ARBA00003023}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000256|ARBA:ARBA00010959}.
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DR AlphaFoldDB; A0A3P9Q984; -.
DR STRING; 8081.ENSPREP00000030717; -.
DR Ensembl; ENSPRET00000031067.1; ENSPREP00000030717.1; ENSPREG00000020800.1.
DR GeneTree; ENSGT00950000183053; -.
DR OMA; CIRFCKI; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000020800; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0042310; P:vasoconstriction; IEA:UniProtKB-KW.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR PANTHER; PTHR13874; ENDOTHELIN; 1.
DR PANTHER; PTHR13874:SF11; ENDOTHELIN-3; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT DOMAIN 73..94
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT DOMAIN 136..154
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT REGION 107..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 154 AA; 16952 MW; 8C203877F2BB9364 CRC64;
MADCLSVDLG ILFIIVVTAS LTNGTLSVSQ RQDVSAEVSL SDPAHQVVIL SGSEAQDRPA
RDPLTARRGR TKRCTCYTYK DKECVYYCHL DIIWINTPEH TVPYGMASSP GSLRTKRSVR
TAQSSRSSRS SGASRRCACT LHTDSECSRF CTNR
//
