ID A0A3P9Q9E4_POERE Unreviewed; 2379 AA.
AC A0A3P9Q9E4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSPREP00000030705.1};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSPREP00000030705.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000030705.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000030705.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000030705.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR Ensembl; ENSPRET00000031055.1; ENSPREP00000030705.1; ENSPREG00000020701.1.
DR GeneTree; ENSGT00940000155359; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000020701; Expressed in caudal fin and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 838..909
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1199..1264
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 2129..2179
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2287..2357
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1531..1576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1605..1647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1725..1771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1816..1864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1994..2027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2182..2256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1015..1162
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1448..1475
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 13..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..300
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..537
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..743
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1411..1432
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1433..1447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1531..1554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1631..1647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1725..1744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1745..1759
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1819..1844
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2008..2027
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2198..2234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2379 AA; 259852 MW; 36B2AA84E883155A CRC64;
MESGERLASP APTLSAARTS SPAASSSSSS SSSSSSPAPH SKSSLAPSPS ALGSTLNTSG
RLFGGAGDQP FIGSTLSSAF PLVNHPAFGA LYTAGAGRPE FGGLGSIGMS AALAAHPQLG
ALTEWWRAAE AHGRGAAAFI PSFIGFPPFF APHIQPNHNT SPVQIRTPGK NSHDPPKGVN
GAVNGSGVCP PTTQSGSYSA SLTPVQAPTK PTRNSDSSNI HRRSPENNPS ELVEKTIVKP
KEKKSRRKPA GASLASHSES GTSSDSSSDG SLSSDLEDLA EEDEDEDDDE EDDEEDDKQS
ELSESEKRIK KKAKVLLPNT GTGKSERSLS REVQVKKDNQ AKKSSRTRTE GPQQHFSVIQ
STGLAANPKP LALLAQPRRE PSPTSSPIAL TTSPRALSST ASPKPPKLLP SSSPQHLPLS
LCSSPKPLSV PSPPCSTLLA STSPKPFGLT SSLTSPQKSS LKPPRHAMSS AAKSNKKKQL
EASLAQISEF RLKQTLMSQG QTFPAEQKKQ QQGPNKSPKR TSLSSPPLPP VPPTPPQNNH
SNLFLSSALL GLPEPHHPNG VIQSTTQDTP LALITKPRKD AASQGRSPQP NSDAGSMPVN
LSTGASRTPA SAQAGPPSQP PTTSPHATGH TSRKSKTPKV KGQTPAPGQA DPLAAWKGFS
QNHLVQSLVD LFRGGESGVG IPGVSIPGVG IPGVGIPGTC NPTAGLPANK ESDDSGDDDD
DDEDDDLEEE DEDDSDDSLS ESDSNSDSDI SGKKVKELKL LPSGSSKKEM TPRRLTKGPE
LLNTSTNHTA TSCSPLNLQV IKSPSVATSS SALAYHSSAG SSSYSLASPL GLGKRKRVMD
EKELMVPLEL GWRRETRIKS VGGRPQGEVS YYAPCGKKLR QYPDVMKYLS RNGISGITRD
NFSFSAKIRV GDFYEAREGP QGLQWSLLKE EEVVPRILAM EGRRGRPPNS ERQLAGEVTK
AGRRRKGRPP NVGDQLVTEG PSPSEVKLLR KLEAQEIARQ AAQMKLMRKL EKQALARAAK
EARRQQAIMA AEERRKQKEQ IKILKQQEKI KRIQQIRMEK ELRAQQILEA KRKKKEEAAN
AKILEAEKRI KEKELRRQQA EILKHQELER HRLDMERERR RQHVMLMKAV EARKKAEERE
RLRQEKRDEK RLNKERKLEQ RRLELEIARE LKKPNEDMCL SDHKPLPEFS RIPGLILPGR
AVSDCLMLMQ FLRGFGKVLG LDLNADVPTL GMLQEGLLNV GDSMGQVQDL LVKLLSLAVC
DPGLPPGQKT KTMLGDHLTN VGINRDNVSE VLQMYMSAHC SNTDLAPLAL SLKTKAFQAH
TPAQKASILG FLANELACSK AVISEIDKNL DQMANMRKDK IIMEGKLKKL KTIHAKRTGK
REASAGVEEN QSLGTPSSAT KRKRKLGGDS DDDDDDDDDS DDQAEDDDDE EEEEIKKVKK
VETFDEDEVD QATSIEELEK QIEKLAKQHH QTRRKLFEIS HSLRSMMYGQ DRYRRRYWVL
PHCGGVFIEA MESGEAPEEL EEERQRRRRA AEEVKVKEEP QEFELHKEKP RSLDGQNLRT
PSLEQQKDEG QEHEGKKNTQ TLFYQQAGCI SKLCTLRNVG KNVSKQSLKA EEKESPLGIQ
DIGPVNIPNA SKKETLPSPN HTTPEPAAAL TPSLVTTNDT TNIPTLASTS LSFPCLPVRQ
ESPGNTPPTS SPHLIFQAND QLLRVLTERS GHWFSLLPRN PCDLSSLTTT PPGAPRGSPQ
ASSTPGRPRS PPPSPALPLT PSAASASASP HHPTGLLNYP LSALQLKSGG SLLGVSFANW
PSGVISPSLP LCSSPSPMPG HSLEGNTTAS VSSKSESPIP RIEKSSSMPS PALEMPKSLD
HPAPRPIPEE LLTGWWRVSH IEQLRALVNA LHSRGIRERG LQRQMQKYLE IIPQVCTKHK
DVAMIELREL EESQVSVESV RGWCVEEQAM EMDIAVLQQV EELERKVTAA SLQVKGWTYP
DPQSEREDLV YYEHKPPTKS TPASGSAGDK DSKEHLEERG EKGGVMRHLD NPLDIAVTRL
ADLERNIERR YLRSPLGTTI QIRLDNVGTV TVPAPAPSSS ADREGGEEEV AHGMKVWRKA
LSEVRSAAQL AMCIQQLQKS IAWERSIMKV YCQMCKKGDN EDLLLLCDGC DKGCHTYCHK
PKITSIPEGD WYCPACISTA SGPSPKTKKP PAKTVASGGG SSKKSGESKK SVKQTGNGEV
SEEDSVSASS TPKKGSKDTS RKRKTEEASP ALIPANQESP VCVKRAKTAR DNNRDLGLCR
VLLAELERHQ DAWPFLTPVN LKSVPGYRKV IKKPMDFSTI REKLVSSQYQ NLETFIIDVN
LVFDNCEKFN EDNSDIGRAG HNMRKFFEKR WTELLKQTN
//
