ID A0A3P9QBT3_POERE Unreviewed; 1583 AA.
AC A0A3P9QBT3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Adhesion G protein-coupled receptor B2 {ECO:0000313|Ensembl:ENSPREP00000031278.1};
GN Name=ADGRB2 {ECO:0000313|Ensembl:ENSPREP00000031278.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000031278.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000031278.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000031278.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR Ensembl; ENSPRET00000031636.1; ENSPREP00000031278.1; ENSPREG00000021037.1.
DR GeneTree; ENSGT00940000160103; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000021037; Expressed in head.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15988; 7tmB2_BAI2; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR InterPro; IPR043838; AGRB_N.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008077; GPCR_2_brain_angio_inhib.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR10239:SF32; ADHESION G PROTEIN-COUPLED RECEPTOR B2; 1.
DR PANTHER; PTHR10239; ISTHMIN-2; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF19188; AGRB_N; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR01694; BAIPRECURSOR.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50092; TSP1; 3.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1583
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018065657"
FT TRANSMEM 870..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 903..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 974..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1012..1035
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1088..1111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 489..559
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 868..1142
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1295..1359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1426..1445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1520..1583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1297..1314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1583 AA; 172422 MW; 2C5A0E081643E61C CRC64;
MNTAGGVCLS VLSSLLAVAG ALAALSALAL APLSTLPEVA YGAAESIPST GAEGGPSPVS
SPCSSLVAGV LYGSFSLREL FPFRTPGCSW SLENPDPTKY SLYLRFTRNP VICQMHHPML
LSLDHHLANQ SCPLHLQTAT ARDQETIDLC GSPLNSDRPY SFLQFDKNFV QLCLTRHPAA
DEPQVTKELA EQRLVEVLLI NNENSSQFTC GVLCRWFEEC LRTDPTGNQE TSDGDVCGMT
QTGCICPNHN IMAPPIPLLP ETPHSFSNGS LVPDDCCVTE LHSNDAIAIA PRDVRQDPYD
DDLKVKTQRP RSADLPGVFQ AQTGDPAAEE WSPWSVCSLT CGQGWQVRTR SCVSSPYGTL
CSGALRETRM CNNTVSCPGE PGIISAVEGQ WLEWGVWSKC SVTCNTGTQM RQRRCSPSVH
GWAECKGLHQ ESRECANPSC SGGGNWGSWN HWSLCSKTCD SGWQRRYRMC EGSGEQGYPC
EGSGEEVRSC NEKKCPAPHE ICKDEHLLSM SWKRASAGET VYNKCPTNVI GSASRRCMLD
NNGVAFWGPP SFARCVSLEY RQLHLALLEH LAKGQRTLAG EGMSQIVRSL LELLQRRSYY
SGDLLFSTEI LRNVTDTFKR ATYIPASDDV QKFFQIVSHM LDLENLEKWE DAHQVAPGAA
SLMRILEDFI HFIGEAQKPF QSFLTVTNNL MITIQREPVS AVSSDINFPM KGRRGMKDWA
RTAEDKLYIP KEVFTIPVEE PGTESETTMY YVIGAILYRT LGIILPGPNP PAVINSKILS
VTVRPEPQPS EPMVVVELSP LLNGTSDPQC VVWNYGNTET GTENWGTEGC QTLASNTVHT
KCLCSRISTY AVLAQQAKDP DMGPTSMPSV PLMVGCGVSC TALLILLLIY AAFWRYIRSE
RSIILVNFCF SILASNLLIL LGQSQTLNKG LCTVTAAFLH FFFLASFCWV LTEAWQSYLA
VIGKTRSRII RKRFLCLGWG LPALVVAVSV GFTRARGYGT ASYCWLSLEG GLLYAFVGPA
AVIVLVNMLI GIVVFNKLMS RDGISDKSKK QRAGVPAEAR SRLLLKCSKC GVISSTAMSS
STASSAMASL WSSCVVLPLL ALTWMSAVLA ITDRRSTLFQ VLFAVFDSVQ GFVIITVHCA
MRREVQDAVR CRMGGCKDDS ENSPDSCKNG QVQIMTDFEK DVDLACQTER GHPFIFKEVN
TCNPATITGT LSRISLDDED DPKLAAHQEG GVGVNFSSLP GNIPPPNLIV QVPTLGLNEL
SETPLKKEVN LDQQRQQGQP RTTAPIYLCT ESGLGWARPP ASSNNSQDGS AGSGGSGGGG
SGGGGEGDYM VLPRRTVSLK PPAPSSQGGG LGLGGEDKPL NIAVEDPPFP PPPSPLTLHP
AESEAYPADF VPSSVGDMNI TMNLNRSYGT IKTVPHGHGH LMGQGGHVHS HGGHMHSHAH
SLHLKPGQRP SVRQILTGGT TVERTRTLPR NLGSTNANTS LSAGSLEKVM HTRKRHSELY
HELNHSSKFH TIDRYNRDPA MSTFKDKSNP EDQSSWDSFK TMTPELSIVP GEQKDRLELH
NKNWDSSSAN TPDSSEGDFQ TEV
//
