ID A0A3P9QCZ2_POERE Unreviewed; 408 AA.
AC A0A3P9QCZ2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Nodal homolog {ECO:0000313|Ensembl:ENSPREP00000032036.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000032036.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000032036.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000032036.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_008416851.1; XM_008418629.1.
DR AlphaFoldDB; A0A3P9QCZ2; -.
DR STRING; 8081.ENSPREP00000032036; -.
DR Ensembl; ENSPRET00000032398.1; ENSPREP00000032036.1; ENSPREG00000021709.1.
DR GeneID; 103470287; -.
DR KEGG; pret:103470287; -.
DR CTD; 338101; -.
DR GeneTree; ENSGT00940000163919; -.
DR OMA; CHQVGDR; -.
DR OrthoDB; 5393576at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13759; TGF_beta_NODAL; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF159; NODAL HOMOLOG; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 277..408
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 200..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 408 AA; 45815 MW; FF02C7A4FDBD6E72 CRC64;
MECRVLAVFC ILSLYTFGAV VSTRTRRHHT HLENGSAHGN MSTNHRSRFP LYMMQLYRSF
SAADSIASLT VNTFAASRDL LSAYSSDSVL SLAAKGCHQV DDRWMVTFDM SSISTSELVQ
LAELQIRLPA FSASHRATVD LYHSHKHSCD PDGTSCQEEP VFLGSFGATP SSTKSSWKVF
NVTRLLKYWL YQGDAVLNQE GSGVTQKDGG SGSGDEDILG RSQRKVQHPT TNRVMMVIFS
KHNLPQDSSG AYSLIHTVEN SKYVTANRAK SDRQSRRHKR NRMLGLRVTD GAAPTVAPAV
EQAQGPLCRK VDMWVDFDHI GWDEWIVHPK RYNAYRCEGE CPIPLDESFN PTNHAYMQSL
LRHHNPGRVS CPSCVPTRLT PLSMLYYEND DLTLRHHEDM IVDECGCH
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