ID A0A3P9QD01_POERE Unreviewed; 1485 AA.
AC A0A3P9QD01;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Rho GTPase-activating protein 35 {ECO:0000256|ARBA:ARBA00040788};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000031919.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000031919.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000031919.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSPRET00000032279.1; ENSPREP00000031919.1; ENSPREG00000021623.1.
DR GeneTree; ENSGT00940000154553; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000021623; Expressed in head and 1 other cell type or tissue.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd22221; pseudoGTPaseD_p190RhoGAP-A; 1.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 1.10.10.440; FF domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 2.
DR InterPro; IPR002713; FF_domain.
DR InterPro; IPR036517; FF_domain_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039007; pG1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR032835; RhoGAP-FF1.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR045786; RhoGAP_pG1_pG2.
DR InterPro; IPR039006; RhoGAP_pG2.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR46005; RHO GTPASE-ACTIVATING PROTEIN 190; 1.
DR PANTHER; PTHR46005:SF1; RHO GTPASE-ACTIVATING PROTEIN 35; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00620; RhoGAP; 2.
DR Pfam; PF16512; RhoGAP-FF1; 1.
DR Pfam; PF19518; RhoGAP_pG1_pG2; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00441; FF; 4.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF81698; FF domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51676; FF; 2.
DR PROSITE; PS51852; PG1; 1.
DR PROSITE; PS51853; PG2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 428..482
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 484..549
FT /note="FF"
FT /evidence="ECO:0000259|PROSITE:PS51676"
FT DOMAIN 592..772
FT /note="PG1 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51852"
FT DOMAIN 800..968
FT /note="PG2 pseudoGTPase"
FT /evidence="ECO:0000259|PROSITE:PS51853"
FT DOMAIN 1157..1404
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 769..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1444..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1485 AA; 168292 MW; 089257BA593244F8 CRC64;
MMAKKQDARS PIYNLIVVGL SGTEKEKGQC GVGKSCLCNR FVRPSADDFY LDHTSVLSTS
DFGGRVVNND HFLFWGEVSR VLEEGPECRM HVVEQTEFID DQTFQPHRST AMQPYIKRAA
ATKLASAEKL MYFCTDQLGL EQDFEQKQMP EGKLQVDGFL LCVDVSRGMN RNFDDQLKFV
TNLYGQLSKT KKPIVLVLTK CDEGVERYIK DAHTFAITKK SLPVVETSAR SNINVDLAFL
TLVQLIDKGR GKPKIIPYFE ALKLQSQQIA SAKDRYEWLI NRIVKNHNET WLNASRRMNN
SPEYKEYVFL EGTAKCKKLF QQHVYRLKQE HIERRRRIYL STLPLALSSL VPDLDEIDQL
SWSGVQKVLE SKQHFTHWFV VLEDSPWEDT SHIDNMEDER IPSDLLETAE AEDIFNAHLE
HLRNECRRAE IRQEFKQKLA SSPFVTPGKP WEEARSFIMN EEFYQWLEEP EYLDLYNRHQ
KEIIDRAKED FQELLLEYSE LFYELEVDAK PSKEKMGAIQ EVLGEEQRFK ALQKLPAERD
ALVLKHIHFV YHPTKETCPS SPHCGDSKIE QLLASRFPTC YPFFDVKAHF GDTKADRINL
VILGKDGLAR EFANEIRALC TNDDWYVLDG KMYELTLRPI EGNVRLPVNS FHTPTFTPHG
CLCLYNSKES LSYVVESLER LRESTLGRRD SQLAQLPTSL LLVTKRGVGS YVDIGGDTAL
NLITQGQQVA RRLQCSFLDP ASPGVGYGHN VNETQINQVL RGLLDVRRST SFSSSSPPLL
PEPPGLRDSP HQPAQEADLR IVMCLMCGDP YDIEQLLSPF LMHQHCRPMS NSGTSVLLEQ
TVGGHKLAIE LSLLSYHASF TLRKSRLVHG YIAVYSVTRK ASLETLCAFL CEVQDIIPVQ
LLAVGDSQAE LTDSDFACEQ LIQGEELAHE IEGRFNSVVC GSGGVVGGLH RIEMFHSFLM
EVVEKRNIVE ATHMYDNVAE ACTGENVYSP RCISPSPVTM FVDSEDDVEP SPPYYDGTLS
SHGGGFNMPD LDSSDISVIS DIRDFENKLN NKIPPQVRVK PGVTFDFRKV SRSPYIDTLG
HRRSLPSAVT WVPGGDVGYD PSDYAEPIDA VSKPRPSNEE IIYSVPHDST QGKIITIRNS
NRMHSNGNGS DSEADSSSLE RRRKFSAIGV KPRLYRDRSK RLGKFSSFRT SFIGSDDEMG
ALSKSKEDDF GTLKGDSLVN EEIEDPKKRN ILKSLRRTAK KTRPKPRPSI PKPMESCYFG
VPLASVVSPD RPIPLFIEKC VHFIEKTGLN TEGLYRVSGN KSEMESMQKQ FEQEIMDREQ
RLYAMKDVLR KFPKENYDVF RYVVSHLNRV SQLSRVNLMT SENLSICFWP TLMRPDFTTM
DALTATRTYQ TIIETFIHQC AFFFYNQPLI DSPTGLGGLP ASPTTTLGGS SAYSCYRSSP
PHTAAHFSPL QQSPPTTPQS PLQSLLPPLH QHPHTHHPPA EQETL
//