ID   A0A3P9QE79_POERE        Unreviewed;       811 AA.
AC   A0A3P9QE79;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Dipeptidyl peptidase like 6 {ECO:0000313|Ensembl:ENSPREP00000032466.1};
GN   Name=DPP6 {ECO:0000313|Ensembl:ENSPREP00000032466.1};
OS   Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Poecilia.
OX   NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000032466.1, ECO:0000313|Proteomes:UP000242638};
RN   [1] {ECO:0000313|Proteomes:UP000242638}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA   Kuenstner A., Dreyer C.;
RT   "The genomic landscape of the Guanapo guppy.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSPREP00000032466.1}
RP   IDENTIFICATION.
RC   STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000032466.1};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_008394612.1; XM_008396390.2.
DR   AlphaFoldDB; A0A3P9QE79; -.
DR   Ensembl; ENSPRET00000032835.1; ENSPREP00000032466.1; ENSPREG00000021954.1.
DR   GeneID; 103456684; -.
DR   CTD; 100007104; -.
DR   GeneTree; ENSGT00940000156280; -.
DR   OrthoDB; 2876738at2759; -.
DR   Proteomes; UP000242638; Unassembled WGS sequence.
DR   Bgee; ENSPREG00000021954; Expressed in head and 1 other cell type or tissue.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF206; DIPEPTIDYL AMINOPEPTIDASE-LIKE PROTEIN 6 ISOFORM X1; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        34..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          133..498
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          592..792
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   811 AA;  92078 MW;  7BFE2FF077D1B3DE CRC64;
     MTTAKEGNAP SKAAQQQDQE LVGSNPPQRN WKGIAIALLV ILVICSLIVT SVILLTPGED
     DRLALKGKVT VGDLFRKEFK VHDPNAKWIS SNELLYRNRD GDVVKYNVDT DDQTVLVQNK
     KFEMYKASRY EVSPDLKHVL LAYNVAPVYQ HSYTAFYIIC SLETPETWNL NPPEVRNAQL
     QFAGWGPQDQ QLIFIFENNI YYRSKVESRS IRLVSTGKES VIFNGLTDWL YEEEIFHSHI
     AHWWSPDGAR LAYATINDTL VPKMELPMFT GSPYPMGKEY PYPKAGEENP VITLYVVNLN
     GPLHTIEMRR PDDPRIGEYY VTMVKWATTT KLAINWLNRA QNISMLTLCE ATTGVCTKKH
     EDESEGWLYR QNEEPLFSKD SLKLFFTRAI PQGGRGKFFH ISMSVSQPNT STDTLQSITS
     GDWDVTQVLA YNEENQLIYF LSTEDGPKRR HLYSADTFGS FNRRCLSCAL ADSCGYISGS
     FSHNMSYFLL NCQGPDIPFV AVYKTQRDAE SETQDRESIS EVSKLESNEN LRLTLDSMQI
     PTVEYREINM DDYILSLKIL KPAGFMDTSH YPLLLLVDGT PGGQTVSERF VLDWATVLVS
     SFGAIVVRCD GRGSGFQGTN VLHRIHKKLG VFEEQDQKDA LDFILKEPYV DQSRVGAFGQ
     VYGGYVTSLL LSGEESPIKC GAVLSPITDF ELYASAFSER YLGLPKPDPR AYTMANLAHR
     ASRFMEKKFL IVHPTADEKV HFQHTAKFIS QLISEKANYT LQIYPDEGHF IHSDATRQHL
     SQSLVNFFEE CFRLPESLFE EDLEEEVEDE G
//