ID A0A3P9QHI9_POERE Unreviewed; 638 AA.
AC A0A3P9QHI9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Forkhead box O1 {ECO:0000313|Ensembl:ENSPREP00000033607.1};
GN Name=FOXO1 {ECO:0000313|Ensembl:ENSPREP00000033607.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000033607.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000033607.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000033607.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC ProRule:PRU00089}.
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DR RefSeq; XP_008425892.1; XM_008427670.2.
DR AlphaFoldDB; A0A3P9QHI9; -.
DR STRING; 8081.ENSPREP00000033607; -.
DR Ensembl; ENSPRET00000033986.1; ENSPREP00000033607.1; ENSPREG00000022772.1.
DR GeneID; 103475797; -.
DR KEGG; pret:103475797; -.
DR CTD; 2308; -.
DR GeneTree; ENSGT00940000161558; -.
DR OMA; NSVHPHS; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR Bgee; ENSPREG00000022772; Expressed in caudal fin.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20060; FH_FOXO1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047408; FH_FOXO1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032067; FOXO-TAD.
DR InterPro; IPR032068; FOXO_KIX-bd.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR PANTHER; PTHR45767:SF9; FORKHEAD BOX PROTEIN O1-B; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16676; FOXO-TAD; 1.
DR Pfam; PF16675; FOXO_KIX_bdg; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638}.
FT DOMAIN 138..232
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 138..232
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 70079 MW; 0758A150771E92BF CRC64;
MAEAPPPQVQ PVDIDPDFEP LPRPRSCTWP LHRPELVDPA GSNTSSPAPS VQQESGGNAE
FISSLGLLEE NYEEYAEDKT HCHVFHHHHQ HHHHLQQQQQ QQLPGPQLPP QQQVSPSGVP
ALGASGQRKI SSSRRNAWGN MSYADLITKA IDSSPEKRLT LSQIYDWMVK SVPYFKDKGD
SNSSAGWKNS IRHNLSLHSR FVRIQNEGTG KSSWWMLNPE GGKNGKSPRR RAVSMDNNNK
FVKSKGRATK KKMSLQEGME GEGSSPGSQY SNWLGSPNSH NNEDFEAWSS FRTRTSSDAS
TLSGRRSPFP SEQEDLVESD GHMLFPATSG TKITSSLPSL SEVSGSMGQH GSERVMESLL
DNLHLLSPKA PQHGSDSPRS PNTARLQSGS YGSPGLSQDY SKCMYSQVRL NSLSPVPMQT
LPENKPGFGG YENQYICPAG LLKELLTADA GSSRDIMPPS DRRVSDTGRV SSLMSAYSSH
NHIASHPGIK IITPPQSHPG LHVNPQSIHS QGPAPSRDLN SCNMIPLTSL TTVSGAPQRL
NRLRTCMQPP QGHLGHTNDF PASYTNSYKE LNLVHPHSHH QERLPSDLDN MPIERLECDL
ESVLHDTLMD GGALDFNFDP AAGFPQRVKS TSHSWVSG
//
