ID A0A3P9QJ43_POERE Unreviewed; 546 AA.
AC A0A3P9QJ43;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSPREP00000034176.1};
OS Poecilia reticulata (Guppy) (Acanthophacelus reticulatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Poecilia.
OX NCBI_TaxID=8081 {ECO:0000313|Ensembl:ENSPREP00000034176.1, ECO:0000313|Proteomes:UP000242638};
RN [1] {ECO:0000313|Proteomes:UP000242638}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Guanapo {ECO:0000313|Proteomes:UP000242638};
RA Kuenstner A., Dreyer C.;
RT "The genomic landscape of the Guanapo guppy.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPREP00000034176.1}
RP IDENTIFICATION.
RC STRAIN=Guanapo {ECO:0000313|Ensembl:ENSPREP00000034176.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3P9QJ43; -.
DR Ensembl; ENSPRET00000034557.1; ENSPREP00000034176.1; ENSPREG00000023119.1.
DR GeneTree; ENSGT00530000063725; -.
DR Proteomes; UP000242638; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096:SF1; PERFORIN 1.5-RELATED; 1.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000242638};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..546
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018332315"
FT DOMAIN 33..362
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
SQ SEQUENCE 546 AA; 61702 MW; 7330CAF8AB94ACDA CRC64;
MCDRSGYVGQ FSSLLLLGVL LVHSSVLSCR TGTQKECDAA PFVPGHNLLG QSFDITTLER
KSAHVIDVKN NLTTRNICIL CSNPLQNDAL QKLPSSVVDF HAIPRCNPEI QSSFHTSAGL
EIEKFLFDNF DVGGTGSNIY KFLSKKIKED RYTFSIHSVT CNHYGFILST TPPLSLEFKQ
QLDLLPSHYN YSTKNEYRKF IQTYGTHYFR MVNLGGRLRR VTSSRSCLSS MNGLTSTQIH
SCLSMGVAVG LGKEQLSSVQ KSCIRVLKNQ DSATGYRSGL HQHFTEVSGG NDWLGEFSIF
QNDSMGYMNW LKSLKEHPDV VSYSLQPLYK LIPSKQQEEM KAAIEHYLED NALWNLPKEP
HCDMTPNVAS NCCPQHASRG TLSVTIVRGW DLFGDDIGPG ERWVDTKVKN KFLINPRWNT
EFKLGMVDTS LPLLIEVWDD DVKYDDLLVQ CRRFLSPGTH TFKCSGLYGN VQVKYTMTCE
PYVTGEKCSH YKPSPLETDD CYVTGRVTKL FGQDLLYAAK RRTRGHIFQP DHRFLAVLWL
KSRGAD
//