ID A0A3Q0CF59_MESAU Unreviewed; 4467 AA.
AC A0A3Q0CF59;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
GN Name=Ryr1 {ECO:0000313|RefSeq:XP_021078799.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021078799.1};
RN [1] {ECO:0000313|RefSeq:XP_021078799.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26319212;
RA Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT "Transcriptome sequencing and development of an expression microarray
RT platform for liver infection in adenovirus type 5-infected Syrian golden
RT hamsters.";
RL Virology 485:305-312(2015).
RN [2] {ECO:0000313|RefSeq:XP_021078799.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [3] {ECO:0000313|RefSeq:XP_021078799.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_021078799.1; XM_021223140.1.
DR STRING; 10036.ENSMAUP00000017731; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 3.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 2.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000313|RefSeq:XP_021078799.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4267..4289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4348..4371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 165..222
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 476..692
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 908..1103
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1252..1465
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1201..1280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1641..1664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2264..2286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2706..2738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3354..3373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3549..3571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4019..4182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1265..1280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4045..4061
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4467 AA; 499455 MW; 95417DC829F1A957 CRC64;
MGDGGEGEDE VQFLRTDDEV VLQCSATVLK EQLKLCLAAE GFGNRLCFLE PTSNAQNVPP
DLAICCFILE QSLSVRALQE MLANTVEAGV ESSQGGGHRT LLYGHAILLR HAHSRMYLSC
LTSSRSITDK LAFDVGLQED ATEWLLGRGP LILILPTVTF PSWSGSHLRW GQPLRIRHVT
TGRYLALTED QGLVVVDASK AHTKATSFCF RISKEKLDVA PKRDVEGMGP PEIKYGESLC
FVQHVASGLW LTYAAPDPKA LRLGVLKKKA MLHQEGHMDD ALSLTRCQQE ESQAARMIYS
TAGLYNQFIK GLDSFSGKPR GSGPPAGSAL PIEGVILSLQ DLIGYFEPPS EELQHEEKQT
KLRSLRNRQS LFQEEGMLSL VLNCIDRLNV YTTAAHFAEF AGEEAAESWK EIVNLLYELL
ASLIRGNRTN CALFSTNLDW LVSKLDRLEA SSGILEVLYC VLIESPEVLN IIQENHIKSI
ISLLDKHGRN HKVLDVLCSL CVCNGVAVRS NQDLITENLL PGRELLLQTN LINYVTSIRP
NIFVGRAEGS TQYGKWYFEV MVDEVAPFLT AQATHLRVGW ALSEGYSPYP GGGEGWGGNG
VGDDLYSYGF DGLHLWTGHV ARPVTSPGQH LLAPEDVVSC CLDLSVPSIS FRINGCPVQG
VFESFNLDGL FFPVVSFSAG IKVRFLLGGR HGEFKFLPPP GYAPCHEAVL PRERLHLQPI
KEYRREGPRG PHLVGPSRCL SHLDFVPCPV DTIQIVLPPH LERIREKLAE NIHELWALTR
IEQGWTYGPV RDDNKRLHPC LVDFHSLPEP ERNYNLQMSG ETLKTLLALG CHVGMADEKA
EDNLKKTKLP KTYMMSNGYK PAPLDLSHVR LTPAQTTLVD RLAENGHNVW ARDRVAQGWS
YSGVQDIPAR RNPRLVPYRL LDEATKRSNR DSLCQAVRTL LGYGYNIEPP DQEPSQVDSQ
SRGDRARIFR AEKSYAVQSG RWYFEFEAVT TGEMRVGWAR PELRPDVELG ADDLAYVFNG
HRGQRWHLGS EPFGRPWQPG DVVGCMIDLT ENTIIFTLNG EVLMSDSGSE TAFRDIEIGD
GFLPVCSLGP GQVGHLNLGQ DVSSLRFFAI CGLQEGFEPF AINMQRPVTT WFSKSLPQFE
PVPLEHPHYE VARMDGTVDT PPCLRLTHRT WGSQNSLVEM LFLRLSLPVQ FHQHFRCTAG
ATPLASPGLQ PPAEDEARAT EPDTDYDNLR RSAGGWGEAE GGKEGTAKEG APGGTAQAGT
EAQPTRAENE KDATTEKNKK RGFLFKAKKV AMMTQPPTTP ALPRLPRDVV PADNRDDPEI
ILNTTTYYYS VRVFAGQEPS CVWVGWVTPD YHQHDMNFDL SKVRAVTVTM GDEQGNVHSS
LKCSNCYMVW GGDFVSPGQQ GRISHTDLVI GCLVDLATGL MTFTANGKES NTFFQVEPNT
KLFPAVFVLP TNQNVVQFEL GKQKNIMPLS AAMFQSERKN PAPQCPPRLE VQMLTPVSWS
RMPNHFLHVD TRRAGERLGW AVQCQEPLMM MALHIPEENR CMDILELSER LDLQRFHSHT
LSLYRSVCAL GNNRVAHALC SHVDQAQLLH ALEDAHLPGP LRAGYYDLLI SIHLESACRS
RRSMLSEYIV PLSPETRAIT LFPPGRSAED GPRRHGLPGV GVTTSLRPPH HFSPPCFVAA
LPGAGAAEAP ARLSPAIPLE ALRDKALRML GEAVRDGGQH ARDPVGGSVE FQFVPVLKLV
STLLVMAPSG FPPPSSPIRS CVDQPPSCLH VLLRLNVPTI YPSIVHFPFN PCDQDLQHRV
ESLAAFAERY VDKLQANQRG RYGLLMKAFT MSAAETARRT REFRSPPQEQ INMLLQFKNG
ADEEDCPLPE EIREDLANFH QDLLAHCGVC VRSCALEYRW LQKPGERGRG RWREGGREGG
LDLGTVENLS GSMCLXQVED MAVSCRERPP LLWFKDTAFC PNPSSESLQE LVSHTVVRWA
QEDFVQSPEL VRAMFSLLHR QYDGLGELLR ALPRAYTISL SSVEDTMSLL ECLGQIRSLL
IVQMGPQEEN LMIQSIGNIM NNKVFYQHPN LMRALGMHET VMEVMVNVLG GGESKEIRFP
KMVTSCCRFL CYFCRISRQN QRSMFDHLSY LLENSGIGLG MQGSTPLDVA AASVIDNNEL
ALALQEQDLE KVVSYLAGCG LQSCPMLLAK GYPDIGWNPC GGERYLDFLR FAVFVNGESV
EENANVVVRL LIRKPECFGP ALRGEGGSGL LAAIEEAIRI SEDPARDGPG VRRDRRREHF
GEEPPEENRV HLGHAIMSFY AALIDLLGRC APEMHLIQAG KGEALRIRAI LRSLVPLEDL
VGIISLPLQI PTLGKDGALV QPKMSASFVP DHKASMVLFL DRVYGIENQD FLLHVLDVGF
LPDMRAAASL DTATFSTTEM ALALNRYLCL AVLPLITKCA PLFAGTEHRA IMVDSMLHTV
YRLSRGRSLT KAQRDVIEDC LMALCRYIRP SMLQHLLRRL VFDVPILNEF AKMPLKLLTN
HYERCWKYYC LPTGWANFGV TSEEELHLTR KLFWGIFDSL AHKKYDQELY RMAMPCLCAI
AGALPPDYVD ASYSSKTEKK ATVDAEGNFD PRPVETLNVI IPEKLDSFIN KFAEYTHEKW
AFDKIQNNWS YGENADEDLK THPMLRPYKT FSEKDKEIYR WPIKESLKAM IAWEWTVEKA
REGEEEKTEK KKTRKISQTA QTYDPREGYN PQPPDLSGVT LSRELQAMAE QLAENYHNTW
GRKKKQELEA KGGGSHPLLV PYDTLTAKEK ARDREKAQEL LKFLQMNGYA VTRGLKDMEL
DTSSIEKRFA FGFLQQLLRW MDISQEFIAH LEAVVSSGRV EKSPHEQEIK FFAKILLPLI
NQYFTNHCLY FLSTPAKVLG SGGHASNKEK EMITSLFCKL AALVRHRVSL FGTDAPAVVN
CLHILARSLD ARTVMKSGPE IVKAGLRSFF ESASEDIEKM VENLRLGKVS QARTQVKGVG
QNLTYTTVAL LPVLTTLFQH IAQHQFGDDV ILDDVQVSCY RTLCSIYSLG TTRNPYVEKL
RPALGECLAR LAAAMPVAFL EPQLNEFNAC SVYTTKSPRE RAILGLPSSV EEMCPDIPVL
ERLMAEIGGL AESGARYTEM PHVIEITLPM LCSYLPRWWE RGPEAPPPAL PAGAPPPCTA
VTSDHLNSLL GNILRIIVNN LGIDEASWMK RLAVFAQPIV SRARPELLHS HFIPTIGRLR
KRAGKVVAEE EQLRLEAKAE AEEGELLVRD EFSVLCRDLY ALYPLLIRYV DNNRAHWLTE
PNPSAEELFR MVGEIFIYWS KSHNFKREEQ NFVVQNEINN MSFLTADNKS KMAKAGDVQS
GGSDQERTKK KRRGDRYSVQ TSLIVATLKK MLPIGLNMCA PTDQDLIVLA KARYALKDTD
EEVREFLQNN LNLQGKVEGS PSLRWQMALY RGVPGREEDA DDPEKIVRRV QEVSAVLYHL
DQTEHPYKSK KAVWHKLLSK QRRRAVVACF RMTPLYNLPT HRACNMFLES YKASWILTED
HSFEDRMIDD LSKAGEQEEE EEEVEEKKPD PLHQLVLHFS RTALTEKSKL DEDYLYMAYA
DIMAKSCHLE EGGENGEEGE EEGSEVSFEE KEMEKQRLLY QQSRLHNRGA AEMVLQMISA
CKGETGAMVS STLKLGISIL NGGNADVQQK MLDYLKDKKE VGFFQSIQAL MQTCSVLDLN
AFERQNKAEG LGMVNEDGTV INRQNGEKVM ADDEFTQDLF RFLQLLCEGH NNDFQNYLRT
QTGNTTTINI IICTVDYLLR LQESISDFYW YYSGKDVIEE QGKRNFSKAM SVAKQVFNSL
TEYIQGPCTG NQQSLAHSRL WDAVVGFLHV FAHMMMKLAQ DSSQIELLKE LLDLQKDMVV
MLLSLLEGNV VNGMIARQMV DMLVESSSNV EMILKFFDMF LKLKDIVGSE AFQDYVTDPR
GLISKKDFQK AVAALLWALV ARAGGAGAGA AAGALRLLWG SLFGGGLVDS AKKVTVTELL
AGMPDPTGDE VHGQQPSGPG GDAEGEGEGE GEGDTADGVG DEEAAADQAG TGGAEGAVAV
ADGSPFRPEG AGGLGDMGDT TPVEPPTPEG SPILKRKLGV DGEEEEPPPE PEPEPEPEKA
ENLKGTPPPT RPRLPMLPRQ TAQRPGTKRA NIRASGVNVH PIRRSTLTSP HFSLRRSFPS
NYWDKFVKRK VLDKHGDIFG RERIAELLGM DLASLEITAH NERKPDPPPG LLTCTILSSV
THNGKQLVMT VGLLAVVVYL YTVVAFNFFR KFYNKSEDED EPDMKCDDMM TCYLFHMYVG
VRAGGGIGDE IEDPAGDEYE LYRVVFDITF FFFVXXXLCP ATPGLIIDAF GELRDQQEQV
KEDMETKCFI CGIGSDYFDT TPHGFETHTL EEHNLANYMF FLMYLINKDE TEHTGQESYV
WKMYQERCWD FFPAGDCFRK QYEDQLS
//
