ID   A0A3Q0CHZ5_MESAU        Unreviewed;       746 AA.
AC   A0A3Q0CHZ5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Prolyl endopeptidase FAP {ECO:0000313|RefSeq:XP_021082195.1};
GN   Name=Fap {ECO:0000313|RefSeq:XP_021082195.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021082195.1};
RN   [1] {ECO:0000313|RefSeq:XP_021082195.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=26319212;
RA   Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT   "Transcriptome sequencing and development of an expression microarray
RT   platform for liver infection in adenovirus type 5-infected Syrian golden
RT   hamsters.";
RL   Virology 485:305-312(2015).
RN   [2] {ECO:0000313|RefSeq:XP_021082195.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=28071753;
RA   McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT   "De novo assembly, annotation, and characterization of the whole brain
RT   transcriptome of male and female Syrian hamsters.";
RL   Sci. Rep. 7:40472-40472(2017).
RN   [3] {ECO:0000313|RefSeq:XP_021082195.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC       Cell projection, invadopodium membrane {ECO:0000256|ARBA:ARBA00004341};
CC       Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004341}.
CC       Cell projection, lamellipodium membrane
CC       {ECO:0000256|ARBA:ARBA00004485}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004485}.
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DR   RefSeq; XP_021082195.1; XM_021226536.1.
DR   AlphaFoldDB; A0A3Q0CHZ5; -.
DR   STRING; 10036.ENSMAUP00000010293; -.
DR   GlyCosmos; A0A3Q0CHZ5; 5 sites, No reported glycans.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002471; Pept_S9_AS.
DR   InterPro; IPR001375; Peptidase_S9.
DR   InterPro; IPR002469; Peptidase_S9B_N.
DR   PANTHER; PTHR11731:SF136; PROLYL ENDOPEPTIDASE FAP; 1.
DR   PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR   Pfam; PF00930; DPPIV_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR   PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE   4: Predicted;
KW   Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT   DOMAIN          106..472
FT                   /note="Dipeptidylpeptidase IV N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00930"
FT   DOMAIN          555..682
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   746 AA;  85626 MW;  DEF44BF137DB36F9 CRC64;
     MKTWMKTVIG VATLAGLALL VICIVLRPSR VHIPERSTRR PLVLKDILNG TFSYKTFFPN
     WISAQEYLHQ SADDNIVFYN VETRESYVIL SNSTMKSVNA SDYGLSPDRQ FAYLESDYSK
     LWRYSYTATY HIYDLRNGEF VRGYELPRPI QYLCWSPVGS KLAYVYQNNV YLKQRPGDPP
     IQITYSGREN KIFNGIPDWV YEEEMLAAKY ALWWSPNGKF LAYAEFNDSD IPIIAYSYYG
     DGQYPRTINI PYPKAGAKNP VVRVFIVDTT YPHHVGPIEV PVPEMIASSD YYFSWLTWVT
     DERICLQWLK RVQNVSVLSI CDFREDWHTW NCPKTQEHIE ESRTGWAGGF FVSTPAFSHD
     ATSYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAIYI FRVTQDSLFY SSNEFEGYPG
     RRNIYRISIG NSPPSKKCVT CHLRKERCQY YTASFSYDAK YYALICYGPG LPISTLHDGR
     TDQEIQILEE NKELENALRN IQLPTEEIKK LEDSELTLWY KMILPPQFDR SKKYPMLIQV
     YGGPCSQSVK SVFAVHWITY LASKEGIVVA LVDGRGTAFQ GDKFLYAVYR KLGVYEVEDQ
     ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASIY
     TERFMGLPTK DDNLEHYKMR NLYCQRNICV AKQPGEYIKA RHPGAEVQSL GTEHIQSSQV
     GSFVCTCSPA LRSVTAGSST VTIVSF
//