ID A0A3Q0CLS0_MESAU Unreviewed; 2474 AA.
AC A0A3Q0CLS0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Centrosomal protein of 290 kDa {ECO:0000313|RefSeq:XP_021081642.1};
GN Name=Cep290 {ECO:0000313|RefSeq:XP_021081642.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021081642.1};
RN [1] {ECO:0000313|RefSeq:XP_021081642.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26319212;
RA Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT "Transcriptome sequencing and development of an expression microarray
RT platform for liver infection in adenovirus type 5-infected Syrian golden
RT hamsters.";
RL Virology 485:305-312(2015).
RN [2] {ECO:0000313|RefSeq:XP_021081642.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000256|ARBA:ARBA00004120}.
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DR RefSeq; XP_021081642.1; XM_021225983.1.
DR STRING; 10036.ENSMAUP00000025704; -.
DR OrthoDB; 3030377at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR InterPro; IPR032321; Cep209_CC5.
DR InterPro; IPR026201; Cep290.
DR PANTHER; PTHR18879; CENTROSOMAL PROTEIN OF 290 KDA; 1.
DR PANTHER; PTHR18879:SF20; CENTROSOMAL PROTEIN OF 290 KDA; 1.
DR Pfam; PF16574; CEP209_CC5; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 1283..1410
FT /note="Centrosomal protein of 290kDa coiled-coil region"
FT /evidence="ECO:0000259|Pfam:PF16574"
FT REGION 128..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2454..2474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 473..559
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 596..651
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 692..747
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 778..858
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 956..1021
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1074..1101
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1215..1242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1284..1393
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1461..1488
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1529..1581
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1617..1888
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1916..1943
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1971..2029
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2066..2448
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2474 AA; 289773 MW; 9FCD841B2E673261 CRC64;
MPPSINWKEL IRVDPDDLPR QEELADNLLI SLSKVEVNEL KDEDQENVIH LFRITQSLMK
MKAQEVELAL EEVEKAGEEQ AKFENQLKTK VMKLENELEM AQQSAGGRDT RFLRDEIRQL
EKQLEQKDRE LEDMEKELDK EKKVNEQLAL RNEEAENENS KLRRENEQLR QDIIDYQKQI
DSQKESLLSR RGEDSDYRSQ LSKKNYELVQ YLDEIQTLTE ANEKIEVQNQ EMRKNLEESV
QEMEKMTDEY NRMKAVVHQT DTVMDQIKKE NEHYRLQVRE LTELLKAKDE EDDPVMMAVN
AKVEEWKLIL SSKDDEIIEY QQMLHSLREK LKNVQLDADK SNIMALKQGI QERDSQIKML
TEQVEQYTKE MEKNTFIIKD LKNELNKDKG TLNFHHQTHY MKIQSKVQIL EEKTKEAERT
AELAEADARE KDKELVEALK RLKDYESGIY GLEDAVIEIK NCKAQIKIRD GEIEVLTKEI
NKLEMKINDV LDENEALREQ AGLEPRTMID LTEFRNSKRL KQQQYRAENQ ILLKEIESLE
EERLDLKKKI RQMAQERGKR NAASGLTIED LNITENFSQE DKMREKNLNF MSLKSMNETQ
SKNEFLSREL IEKERDLERS RTVIAKFQSK LKELVEENKQ LEEGMKEILQ AIKDMPRDPD
VKGSETSLII PSLERLVNAI ESKNTEGIFD ASLHLKAQVD QLTGRNEELR QELRESRKEA
ISYSQQLVKA NSKIDHLEKE TDLLRQSAGS NVVYKGVDLP DGIAPSSAHI INSQNEYLIH
LLQELDNKEK KLKHVEESLE DYNRKFAVIR HQQSLLYKEY LSEKETWKTE SETVKEEKRK
LEDQVQQDAV RVKEYNNLLS ALQMDSNEMK KMLSENSRKI TVLQVNEKSL IRQYTTLVEM
ERQLRKENGK HKNDLISMEA EVTEKIGSLQ RFKEMATFKI AALQKVVDNS VSLSELELAN
KQYNELTTKY RDILQKDNML VQRTSNLEHL ECENASLKEQ MDAISKELEI TKEKLHTIEQ
AWEQETKLGN ESNMDKARKS MTNSDIVSIS KKITVLEMKE LNERQRAEHC QKMYEHVRTS
LKQMEERNFE LETKFTELTK IHLDAQKVEQ MLRDELADSV NKAVSNADRQ RILELEKNEV
ELKVEVSKLR EISDIAKRQV DFLNSQQQSR EKEVESLRMQ LLDYQAQSDE KALIAKLHQH
VVSLQISEAT ALGKLESITS KLQKMEAYNL RLEQKLDEKE QTLYYARLEG RNRAKHLRQT
IQSLRRQYSG ALPLAQQEKF SKTMIQLQND KLKIMQEMKN SQQEHRNMEN KTLELELKLK
GLEELISTLK DARGAQKVIN WHVKIEELRL QELKLNRELV KGKEEIKYLN NIISEYEQTI
NSLEEEIVQQ NKFHEERQMA WDQREVELER QLDLFDCQQN EILSAAQKFE EATGSMPDPS
LPLPNQLEIA LRKIKENIQT ILKTQATCKS LEEKLKEKES ALQLAEQNIL SRDKVINELR
LRLPATVDRE KLIAELDSKE LEPKSHHTMK IAHQTIANMQ ARLNQKEEVL KKYQHLLERA
REEQREIVKK HEEDLHALHH KLELQADSSF NKFKQTAQDL IKQSPVPVPT DKHFIRLAEM
EQTVAEQDDS LASLLAKLKK VSKDLERQKE ITELKVREFE NTKLRLQEKH SGEVKKVRAE
VEDLRRALVH AQKESQRVKS ELQAQKEANS RAPTTTMRNL VDRLKSQLAL KEKQQKALSR
ALLELRAEMT AAAEERIIAV TSQKEANLNI QQVVDRHTRE LKSQIENLNE NLLKLKEALK
TSKNKENSLA DDLNDLNNEL QKKQKAYNKI LREKDGIDQE NEELRRQIKR LSSGLQSKPL
LDNKQSLIDE LQKKVKKLES QLERKVDGID IKPVKEKSAR EELIRWEEGK KWQTKVEGMR
NKLKEKEGEV HSLMKQLHTL KELFAKADKE KLTLQKKLKT TGMTVDQVLG VRALESEKEL
EELKKRNLDL ENDILYMRTH HALPRDSVVE DLHLQNKYLQ EKLRTLEKQL SKDLYPQSVT
SEVESDDHCQ KEQELQRENL KLSSENIELK FQLEQANKDL PRLKNQVRDL KEMCEFLKKG
KMEVERKLGQ VRGSGRSGKT VPELEKTIGL MKKVVEKVQR ENEQLQKASG ILTSEKMINI
EEENEKLKVE LEKLKAHFGR QLSVQYESKN KSTERIVAEN ERLRKELKKE METSENLRIA
KNNLELVNDK MALQLEETAK RLQFAESRVP QLESADSKSW KSIVLTRMYE TKMKELESDI
AKKNQSIVDL KQLVREATER EQKAKKYTED LEQQIEALRN IPEGVETDQG LIRELQLLRL
ANSKLDKEKA ELIHQIEANK DQTGAESSTP ALADSDQLKE KVNDLETQLR NSDLDKQHLK
EEIKKLKKEL ENFDPSFFEE IEDLKYNYKE EVKKNILLEE KLKKLSEQFG FELPSPVAAS
EQREDGESPN QFPI
//
