ID   A0A3Q0CLU8_MESAU        Unreviewed;      1243 AA.
AC   A0A3Q0CLU8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Polyserase-2 {ECO:0000313|RefSeq:XP_021081671.1};
GN   Name=Prss36 {ECO:0000313|RefSeq:XP_021081671.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021081671.1};
RN   [1] {ECO:0000313|RefSeq:XP_021081671.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_021081671.1; XM_021226012.1.
DR   AlphaFoldDB; A0A3Q0CLU8; -.
DR   STRING; 10036.ENSMAUP00000010261; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00190; Tryp_SPc; 2.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 5.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   InterPro; IPR033116; TRYPSIN_SER.
DR   PANTHER; PTHR24253:SF159; PROSTASIN; 1.
DR   PANTHER; PTHR24253; TRANSMEMBRANE PROTEASE SERINE; 1.
DR   Pfam; PF00089; Trypsin; 4.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 3.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 4.
DR   PROSITE; PS50240; TRYPSIN_DOM; 4.
DR   PROSITE; PS00134; TRYPSIN_HIS; 2.
DR   PROSITE; PS00135; TRYPSIN_SER; 2.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|RuleBase:RU363034};
KW   Protease {ECO:0000256|RuleBase:RU363034};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Serine protease {ECO:0000256|RuleBase:RU363034};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1243
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018108544"
FT   DOMAIN          47..291
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   DOMAIN          326..560
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   DOMAIN          606..813
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   DOMAIN          946..1187
FT                   /note="Peptidase S1"
FT                   /evidence="ECO:0000259|PROSITE:PS50240"
FT   REGION          20..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          296..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1243 AA;  134126 MW;  6E80E61198119C7C CRC64;
     MSQHLFLPVV MMVVSPIPGT SQDSAISPTQ GESEDLDCGH PEPSSRIVGG SDARPGTWPW
     QVSLHHGGGH ICGGSLIAPS WVLSAAHCFV TNETLEPADE WSVLLGVHSQ DGPMDGAHLR
     SVAAILVPDN YSRVELGSDV ALLRLASPAR LSPSVRPVCL PRASHRFAHG TACWATGWGD
     VQEADPLPLP WVLQEVELRL LGEAACQCLY SRPGPFNLTF QLLPGMLCAG YPEGRRDTCQ
     GDSGGPLVCE DGGRWFQAGI TSFGFGCGRR NRPGVFTAVA PYESWIREQV MGSEPGPAFP
     SQLHKPQSGP QEPREENCTF AQPECGKASR PGIWPWEAQV MVPGSRPCYG VLVSDSWVLA
     PASCSLDYPI QQPRTSDSPP RDLEAWRVLL PSRPEGERVA RLVPHENASK DSASDLALLQ
     LRTRVNLTAA PSAVCLPHPE HFFLPGSRCR LARWGRGEPA PGSSAQLEAQ LMNSWWCHCL
     YGRQGASVPP PGDPPHLLCP AYLEEEEAGQ CWKDAGWSLL CREEGTWFLA GHRTLSNGCL
     RPRAFSPLQT HGPWISHVTQ GAYLEDQLTW DWGPEGEETE KQICPPHTEH GACGLRPKAT
     PAGALWPWLT EVHVTGNRVC TGILVAPGWV LAATHCILRL GSTTVPYIEV YLGQAGARSL
     PQGHQVSRSV ISIRLPRHLG LRPPLALLEL NSQVEPSPSA LPICLQPGGI PPGASCWVLG
     WKDPQDRVPV AAAVTILTPR LCHCLYQGIL TPGTFCVLYT EGQEDKCEVT SAPPLLCQTE
     GGPWVLMGMA VRGSQELFAA IGPEAAWISQ TVGEAHFLPP SGSPYWPPED SDLCHQDLAG
     AASSPRAAAL LLLPLAPLIQ GILGFLLPSR HPDPAFKASL PFLPFLPRVS RPPARELSTW
     AMALMVGRGP GQREAVAILL LMGLLQPRTG AAGAEASCGV VMQPRITGGS SAKPGQWPWQ
     VSITYDGIHV CGGSLVSDQW VVSAAHCFPR EHYRDQYEVK LGAHQLDSYS NDTVVRTVAR
     IISHSSYREE GSQGDIALVH LSSPVNFSRH IKPICLPAAN ASFPNGLHCT VTGWGHVAPS
     VSLQTPKPLQ QLEVPLISRE TCSCLYNINA VPEEPHTIQP DMLCAGYVEG GKDACQGDSG
     GPLSCPIEGL WYLAGIVSWG DACGAPNRPG VYTLTSTYAS WIHHNVAELQ PRMVPQTQES
     QPDGHLCNHH HVFNSAAAQG LLRPLPFLPL GLTLGLFCLW FEH
//