ID A0A3Q0CQ94_MESAU Unreviewed; 430 AA.
AC A0A3Q0CQ94;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Signal transducer and activator of transcription 5A {ECO:0000256|ARBA:ARBA00040515};
GN Name=LOC101842510 {ECO:0000313|RefSeq:XP_021082867.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021082867.1};
RN [1] {ECO:0000313|RefSeq:XP_021082867.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [2] {ECO:0000313|RefSeq:XP_021082867.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586}.
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DR RefSeq; XP_021082867.1; XM_021227208.1.
DR AlphaFoldDB; A0A3Q0CQ94; -.
DR STRING; 10036.ENSMAUP00000004712; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007595; P:lactation; IEA:UniProtKB-KW.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF47; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lactation {ECO:0000256|ARBA:ARBA00043262};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 226..323
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 430 AA; 48636 MW; 7016E34369B7C01D CRC64;
MNPPQVKATI ISEQQAKSLL KNENTRNECS GEILNNCCVM EYHQATGTLS AHFRNMSLKR
IKRADRRGAE SVTEEKFTVL FESQFSVGSN ELVFQVKTLS LPVVVIVHGS QDHNATATVL
WDNAFAEPGR VPFAVPDKVL WPQLCEALNM KFKAEVQSNR GLTKENLVFL AQKLFNSSSS
HLEDYNSMSV SWSQFNRENL PGWNYTFWQW FDGVMEVLKK HHKPHWNDGA ILGFVNKQQA
HDLLINKPDG TFLLRFSDSE IGGITIAWKF DSPDRNLWNL KPFTTRDFSI RSLADRLGDL
SYLIYVFPDR PKDEVFAKYY TPVLAKAADG YVKPQIRQVV PEFISASADA GANATYMDQA
PSPVVCPQPH YNMYPQNPDP VLDQDGEFDL DETMDVARHV EELLRRPIDS LDSRLSPPAG
LFTSARGSLS
//
