ID A0A3Q0CQA5_MESAU Unreviewed; 1576 AA.
AC A0A3Q0CQA5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=CLIP-associating protein 1 isoform X2 {ECO:0000313|RefSeq:XP_021082876.1};
GN Name=Clasp1 {ECO:0000313|RefSeq:XP_021082876.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021082876.1};
RN [1] {ECO:0000313|RefSeq:XP_021082876.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi
CC apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
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DR RefSeq; XP_021082876.1; XM_021227217.1.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 319..551
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 887..1125
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1327..1565
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 235..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..708
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..814
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1576 AA; 173536 MW; F72413643B42177C CRC64;
MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDKQKSADL EHDQTMLDKL VDGLATSWVN
SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL GDAKDSVREQ DQTLLLKIMD
QAANPQYVWD RMLGGFKHKN FRTREGICLC LIATLNASGA QTLTLSKIVP HICNLLGDPN
SQVRDAAINS LVEIYRHVGE RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANDKN
FDDEDSVDGN RPSSASSSSS KAPSSSRRNV SMGTTRRLVS SSLGSKSSAA KEGAGAVDEE
DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKMRS LLLAGAAEYD
NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG NKFDHGAEAI MPTIFNLIPN
SAKIMATSGV VAVRLIIRHT HIPRLIPVIT SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL
ERHISVLAET IKKGIHDADS EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL
KNSDSIVSLP QSDRSSSSSQ ESLNRPLSAK RSPTGSTTSR ASTVSTKSAS TAGSLQRSRS
DIDVNAAASA KSKVSSSSGS TAFSSAAALP PGSYASLESR HVREDLEYVG LDAGRIRTRR
QSSGSATNVA STPSDSRGRS RAKVVSQSQR SRSANPAGAG SRSSSPGKLL GSGYGGLAGG
SSRGPPVTLS SEKRSKIPRS QGCSRETSPN RIGLARSSRI PRPSMSQGCS RDTSRESSRD
TSPARGFAPL ASRRHSRSTS ALSTAESVGQ SDRFGLGQSG RIPGSVNAMR VLSTSTDLEA
AVADALKKPV RRRYEPYGMY SDDDANSDAS SVCSERSYGS RNGGIPHYLR QTEDVAEVLN
HCASSNWSER KEGLLGLQNL LKSQRTLSRV ELKRLCEIFT RMFADPHSKR VFSMFLETLV
DFIIIHKDDL QDWLFVLLTQ LLKKMGADLL GSVQAKVQKA LDVTRDSFPF DQQFNILMRF
IVDQTQTPNL KVKVAILKYI ESLARQMDPT DFVNSSETRL AVSRIITWTT EPKSSDVRKA
AQIVLISLFE LNTPEFTMLL GALPKTFQDG ATKLLHNHLK NSSNTSVGSP SNTIGRTPSR
HPSSRTSPLT SPTNCSHGGL SPSRLWGWSA DGLSKPPPPF SQPNSIPTAP SHKTLRRSYS
PSMLDYDTEN LNSEEIYSSL RGVTEAIEKF SFRSQEDLNE PIKRDGKKDC DIVSRDGGAA
SPATEGRGGG EMEGGRMALD NKTSLLNTQP PRAFPGPRAR EYNPYPYSDT INTYDKTALK
EAVFDDDMEQ LRDVPIDHSD LVADLLKELS NHNERVEERK GALLELLKIT REDSLGVWEE
HFKTILLLLL ETLGDKDHSI RALALRVLRE ILRNQPARFK NYAELTIMKT LEAHKDSHKE
VVRAAEEAAS TLASSIHPEQ CIKVLCPIIQ TADYPINLAA IKMQTKVVER ITKESLLQLL
VDIIPGLLQG YDNTESSVRK ASVFCLVAIY SVIGEDLKPH LAQLTGSKMK LLNLYIKRAQ
TTNSNSSSSS DVSTHS
//
