ID A0A3Q0CR94_MESAU Unreviewed; 4392 AA.
AC A0A3Q0CR94;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Ankyrin-3 isoform X4 {ECO:0000313|RefSeq:XP_021083222.1};
GN Name=Ank3 {ECO:0000313|RefSeq:XP_021083222.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021083222.1};
RN [1] {ECO:0000313|RefSeq:XP_021083222.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_021083222.1; XM_021227563.1.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08803; Death_ank3; 1.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR037971; Ank3_Death.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 2.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 22.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 21.
DR PROSITE; PS50088; ANK_REPEAT; 21.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 67..99
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 100..132
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 133..165
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 166..189
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 236..268
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 269..301
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 302..334
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 335..367
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 368..400
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 401..433
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 434..466
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 467..499
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 500..532
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 533..565
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 566..598
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 599..631
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 632..664
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 665..697
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 698..730
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 731..763
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 764..796
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 997..1185
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1187..1334
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 4106..4190
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1643..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2017..2037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2049..2068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2113..2134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2149..2202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2218..2304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2332..2365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2391..2475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2516..2551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2632..2821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2868..2913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2982..3027
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3083..3114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3175..3306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3333..3549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3572..3641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3669..3704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3848..3887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3900..3929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4040..4103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4258..4315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4332..4392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2154..2171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2172..2188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2261..2290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2415..2429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2448..2475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2524..2538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2632..2659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2660..2678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2749..2763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2767..2787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2802..2816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3087..3101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3175..3228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3249..3278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3370..3385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3406..3440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3496..3530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3588..3604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3611..3634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3683..3703
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3871..3886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3902..3916
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4040..4055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4056..4073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4349..4392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4392 AA; 479993 MW; FF0552F519700809 CRC64;
MACSGTSSPG GTGNPEPEQG DFGSYISRSS QKSDANASYL RAARAGHLEK ALDYIKNGVD
INICNQNGLN ALHLASKEGH VEVVSELLQR DANVDAATKK GNTALHIASL AGQAEVVKVL
VTNGANVNAQ SQNGFTPLYM AAQENHLEVV RFLLDNGASQ SLATEDGFTP LAVALQQGHD
QVVSLLLEND TKGKVRLPAL HIAARKDDTK AAALLLQNDN NADVESKMVV NRATESGFTP
LHIAAHYGNI NVATLLLNRA AAVDFTARND ITPLHVASKR GNANMVKLLL DRGAKIDAKT
RDGLTPLHCG ARSGHEQVVE MLLDRAAPIL SKTKNGLSPL HMATQGDHLN CVQLLLQHNV
PVDDVTNDYL TALHVAAHCG HYKVAKVLLD KKANPNAKAL NGFTPLHIAC KKNRIRVMEL
LLKHGASIQA VTESGLTPIH VAAFMGHVNI VSQLMHHGAS PNTTNVRGET ALHMAARSGQ
AEVVRYLVQD GAQVEAKAKD DQTPLHISAR LGKADIVQQL LQQGASPNAA TTSGYTPLHL
SAREGHEDVA AFLLDHGASL SITTKKGFTP LHVAAKYGKL EVANLLLQKS ASPDAAGKSG
LTPLHVAAHY DNQKVALLLL DQGASPHAAA KNGYTPLHIA AKKNQMDIAT SLLEYGADAN
AVTRQGIASV HLAAQEGHVD MVSLLLSRNA NVNLSNKNGL TPLHLAAQED RVNVAEVLVN
QGAHVDAQTK MGYTPLHVGC HYGNIKIVNF LLQHSAKVNA KTKNGYTPLH QAAQQGHTHI
INVLLQNNAS PNELTVNGNT ALAIARRLGY ISVVDTLKVV TEETMTTTTI IEKHKMNVPE
TMNEVLDMSD DEVRKANAPE KLSDGEYISD VEEGEDAITG DTDKYLGPQD LKELGDDSLP
AEGYVGFSLG ARSASLRSFS SDRSYTLNRS SYARDSMMIE ELLVPSKEQH LTFTREFDSD
SLRHYSWAAD TLDNVNLVSS PVHSGYSSPL PQYDSRFLVS FMVDARGGSM RGSRHHGMRI
IIPPRKCTAP TRITCRLVKR HKLANPPPMV EGEGLASRLI EMGPAGAQFL GKLHLPTHPP
PVNEGESLVS RILQLGPQGT KFIGPVIVEI PHFGSMRGKE RELIVLRSEN GETWKEHQFD
SKNEDLAELL NGMDEELDSP EELGTKRICR IITKDFPQYF AVVSRIKQES NQIGPEGGIL
SSTTVPLVQA SFPEGALTKR IRVGLQAQPV PEEIVKKILG NKATFSPIVT VEPRRRKFHK
PITMTIPVPP PSGEGVSNGY KGDTTPNLRL LCSITGGTSP AQWEDITGTT PLTFIKECVS
FTTNVSARFW LADCHQVLET VGLASQLYRE LICVPYMAKF VVFAKTNDPV ESSLRCFCMT
DDRADKTLEQ QENFEEVARS KDIEVLEGKP IFVDCYGNLA PLTKGAQQLV FNFYSFKENR
LPFSIKIRDT SQEPCGRLSF LKEPKTTKGL PQTAVCNLNI TLPAHKKETE SDQDDEAEKA
DRRQSFASLA LRKRYSYLTE PGMKTVERSS GTARTLPTTY SYKPFFPTRP YQSWTTAPVS
VPGPAKSGFA SLSSSSSNTP SASPLKSIWS VSTPSPIKST LGASTTSSVK SISDVASPIR
SFRTISSPIK TVVSPSPYNI QVTSGTLGRP PTVTTEATPL KGLAPTSTFS SRTSPVTTAG
SLLERSSITM TPPASPKSNI TMYSSSLPFK SIITSAAPLI SSPLKSVVSP TKSAADVISS
AKATMASSLS SPLKQMSGHA EVALVNGSVS PLKYPSSSSL INGCKATATL QDKISTATNA
VSSVVSAATD TVEKALSTTT AMPFSPLRSY VSATPSSAFQ SLRTPSASAL YTSLGSSLSA
TTSSVTSSII TVPVYSVVNV LSEPALKKLP DSNSLTKSAA ALLSPIKTLT TETRPQPHFN
RTSSPAKSSL FLTPSALKLS APSSLSSSQE ILKDVAEMKE DLMRMTAILQ TDVPEEKPFQ
PDLPKEGRID DEEPFKIVEK VKEDLVKVSE ILKKDVCVDS KGPPKSPKSD KGHSPEDDWI
EFSSEEIREA RQAAASHTPS PSEKVHGKAN LTRVIDYLTN DIGSSSSLTN LKYKFEDAKK
DGEERQKRIL KPAMALQEHK LKMPPASMRP STSEKELCKM ADSFFGSDAI LESPDDFSQH
DQDKSPLSDS GFETRSEKTP SAPQSAESTG PKPLFHEVPI PPVITETRTE VVHVIRSYEP
STGDIPQSQP EDPMSPKPSA TFMELEPKPT TSSIKEKVKA FQMKASSEEE DHSRVLSKGM
RVKEETHITT TTRMVYHSPP GSECASERIE ETMSVHDIMK AFQSGRDPSK ELAGLFEHKS
AMSPDVPKSA AEISAQHAEK DSQMKPKLER IIEVHIEKGN QAEPTEVIIR ETKKHPEKEV
PGCQKDLSRG SINLKDFLPE KHDAFPCPEE QGQQEEEELA AEESLPSYLE SSRVNTPVSQ
EEDSRPSSAQ LLSDDSYKTL KLLSQHSVEY HDDELSDLRG ESYRFAEKML LSEKLDVSHS
DTEESVTDPV GPPSSQLQRS DKRSRDKVAT APQKEILSKI YKDVSENGVG RVSKDEHFDK
MTVLHYAGNV SGPKHAMWMH LSEDRLDRGR EKLIYEDRVD RTVKEAEEKL TEVSQFFRDK
TEKLNDELQS PEKKPRPQNG KEYSSQSSTS SSPEKVLTEL LASNDEWVKA RQRGQDGQGV
PQAEDKKTCI GSSSPEKRVP SQQSEDGQPT EEAKRTVIAQ GRGPEGPQSG FQLKQSKLSS
IRLKFEQGTR AKSKDLSQEE KTLDGPSRIP VKKTQESKLP THPGFAREKQ QKAVDLSEER
GPVQNDVTIV KVEHAKNNDI VVNESGPDDV KRHRTEMLSK AMPEFFPEQQ AEEDSACSMT
SDLATKGPWD RKGFRTWESS GANNNKAQKE KLSHVLVHDI RQSHTGRPDE SENADPKNEF
MCVTEREHKL LTNGSLSEIK EMSVKSPSKK VLYREYIVKE GDRPPSGALD RLPRRSESSV
GSHIPIRVAD ERKMPSSNIP DGFCEQSTFP KHELSQKVTR SRVSKEIVEN QHFNSIDDEK
VTYSEISKVS KQSYVGLCPV LDETETSPIR SPDSLEFSPG KDSPSSDVFD HGSMEGLEKL
APLAQTEGGK EIKTLPVYVS FVQVGKQYEK ELQQGGVKKI ISQECKTVQE ARGTFYTARQ
QKQPPSPQGS PEDDTLEQVS FLDSSGKSPL TPETPSSEEV SYEFTSKTPD SLIAFIPGQP
SPIPEVSEES ESEEPKSAPL KQVTVERETD RNVSKDSTQR SKCNRVAYIE FPPPPPLDAD
QMESDKKHQY LPEREVDMIE VNLQDECDKY QLAEPVIRVQ PPSPVPPGAE ASDSSDDESM
YQPVPVKKYT FKLKEVDEGQ KDMAKSKTAA MKASNQKEAE SNGRESESGL DSPQNETAQN
GNNDQSVTEC SIATTAEFSH DTDATEIDSL DGYDLQDEDD GLTESDSKLP SQTVDTKKDV
WTEGILKPAD RSFSQSKLEV IEEEGKVGLD EEKPSSSKSS SSDRTPEKSD PKSGTQFFTL
EGRHPDRSVF PDTYFSYKVD EEFATPFKTV ATKGLDFDPW PNNRGDNEVF DGKSREDDTK
PFGLAVDDRS PATTPDTTPA RTPTDESTPT SEPNPFPFHE GKMFEMTRSG AIDMSKRDFV
EERLQFFQIG EHTPEGKSGA QGEGDNSMVT DTPQPQSGDT SVDTNLERDV EAPTVEPNPS
IPTIGECQEG AACSGSLEKS TAAANTSKVD PKSRTPIKMG ISASTMTMKK EGSGEVTDKI
EAVVTSCQGL ENEMVTVISS APNSQVGVRS QEKHDFQKDN FNNNNNLDSS TMQTDNTTNH
VVLTGRAAPT RTTEKANPVK GSGKSPGTQG HCIRDSRKEP IGVRRKSKLP IKATAPKDVF
LSNHKPDSKA GKLRQVGPSE KNKTLPTSSC VDAKSRIPVK NTHRENLVSV RKACATQKRG
QPEKGKAKLP PSKLPVKVRS TCVTVTTTNT ITTTTTTTKS TTVKVRESQL KAVCKHPIEY
FKGISGETLK LVDRLTEEDK KMQSELSDEE ESTSRNTSLS ETSRGGQPSV TTKSARHKRT
EATPLKSKSG KAGSRRTGPQ SPCERTDIRM AIVADHLGLS WTELARELNF SVDEINQIRV
ENPNSLISQS FMLLKKWVTR DGKNATTDAL TSVLTKINRI DIVTLLEGPI FDYGNISGTR
SFADENNVFH DPVDGWQNET SSGSLESPAQ ARRITGGLLD RLDDSTDQVR DSITSYLKGE
PGKFEANGSH AEVTPEAKAK SYFPESQNDI GKQSIKENLK PKTHGSSRTE EPASPLTAYQ
KSLEETSKFV IEDAPKPCVP VSMKKMTRTS ADGKARLNLH EEEGSSGSEP KQGEGYKMKT
KKEIRNVEKK TH
//
