ID A0A3Q0CS52_MESAU Unreviewed; 1536 AA.
AC A0A3Q0CS52;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=CLIP-associating protein 1 isoform X23 {ECO:0000313|RefSeq:XP_021082884.1};
GN Name=Clasp1 {ECO:0000313|RefSeq:XP_021082884.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021082884.1};
RN [1] {ECO:0000313|RefSeq:XP_021082884.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000256|ARBA:ARBA00004300}. Golgi
CC apparatus, trans-Golgi network {ECO:0000256|ARBA:ARBA00004601}.
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DR RefSeq; XP_021082884.1; XM_021227225.1.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF28; CLIP-ASSOCIATING PROTEIN 1; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 319..551
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 886..1124
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1287..1525
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 235..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1117..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1201..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 250..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..627
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..699
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..805
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1536 AA; 169219 MW; E8F4CE11CA5C27A3 CRC64;
MEPRMESCLA QVLQKDVGKR LQVGQELIDY FSDKQKSADL EHDQTMLDKL VDGLATSWVN
SSNYKVVLLG MDILSALVTR LQDRFKAQIG TVLPSLIDRL GDAKDSVREQ DQTLLLKIMD
QAANPQYVWD RMLGGFKHKN FRTREGICLC LIATLNASGA QTLTLSKIVP HICNLLGDPN
SQVRDAAINS LVEIYRHVGE RVRADLSKKG LPQSRLNVIF TKFDEVQKSG NMIQSANDKN
FDDEDSVDGN RPSSASSSSS KAPSSSRRNV SMGTTRRLVS SSLGSKSSAA KEGAGAVDEE
DFIKAFDDVP VVQIYSSRDL EESINKIREI LSDDKHDWEQ RVNALKKMRS LLLAGAAEYD
NFFQHLRLLD GAFKLSAKDL RSQVVREACI TLGHLSSVLG NKFDHGAEAI MPTIFNLIPN
SAKIMATSGV VAVRLIIRHT HIPRLIPVIT SNCTSKSVAV RRRCFEFLDL LLQEWQTHSL
ERHISVLAET IKKGIHDADS EARIEARKCY WGFHSHFSRE AEHLYHTLES SYQKALQSHL
KNSDSIVSLP QSDRSSSSSQ ESLNRPLSAK RSPTGSTTSR ASTVSTKSAS TAGSLQRSRS
DIDVNAAASA KSKVSSSSGS TAFSSAAALP PGSYASLESR HVREDLEYVG LDAGRIRTRR
QSSGSATNVA STPSDSRGRS RAKVVSQSQP GSRSSSPGKL LGSGYGGLAG GSSRGPPVTL
SSEKRSKIPR SQGCSRETSP NRIGLARSSR IPRPSMSQGC SRDTSRESSR DTSPARGFAP
LASRRHSRST SALSTAESVG QSDRFGLGQS GRIPGSVNAM RVLSTSTDLE AAVADALLLG
DARSKKKPVR RRYEPYGMYS DDDANSDASS VCSERSYGSR NGGIPHYLRQ TEDVAEVLNH
CASSNWSERK EGLLGLQNLL KSQRTLSRVE LKRLCEIFTR MFADPHSKRV FSMFLETLVD
FIIIHKDDLQ DWLFVLLTQL LKKMGADLLG SVQAKVQKAL DVTRDSFPFD QQFNILMRFI
VDQTQTPNLK VKVAILKYIE SLARQMDPTD FVNSSETRLA VSRIITWTTE PKSSDVRKAA
QIVLISLFEL NTPEFTMLLG ALPKTFQDGA TKLLHNHLKN SSNTSVGSPS NTIGRTPSRH
PSSRTSPLTS PTNCSHGGLS PSMLDYDTEN LNSEEIYSSL RGVTEAIEKF SFRSQEDLNE
PIKRDGKKDC DIVSRDGGAA SPATEGRGGG EMEGGRMALD NKTSLLNTQP PRAFPGPRAR
EYNPYPYSDT INTYDKTALK EAVFDDDMEQ LRDVPIDHSD LVADLLKELS NHNERVEERK
GALLELLKIT REDSLGVWEE HFKTILLLLL ETLGDKDHSI RALALRVLRE ILRNQPARFK
NYAELTIMKT LEAHKDSHKE VVRAAEEAAS TLASSIHPEQ CIKVLCPIIQ TADYPINLAA
IKMQTKVVER ITKESLLQLL VDIIPGLLQG YDNTESSVRK ASVFCLVAIY SVIGEDLKPH
LAQLTGSKMK LLNLYIKRAQ TTNSNSSSSS DVSTHS
//
