ID A0A3Q0CTK3_MESAU Unreviewed; 1552 AA.
AC A0A3Q0CTK3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=CLIP-associating protein 2 isoform X4 {ECO:0000313|RefSeq:XP_021085725.1};
GN Name=Clasp2 {ECO:0000313|RefSeq:XP_021085725.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021085725.1};
RN [1] {ECO:0000313|RefSeq:XP_021085725.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|ARBA:ARBA00004601}.
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DR RefSeq; XP_021085725.1; XM_021230066.1.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0008017; F:microtubule binding; IEA:UniProt.
DR GO; GO:0051494; P:negative regulation of cytoskeleton organization; IEA:UniProt.
DR GO; GO:1902904; P:negative regulation of supramolecular fiber organization; IEA:UniProt.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF30; CLIP-ASSOCIATING PROTEIN 2; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 3.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..232
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 168..206
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 317..550
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1309..1540
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 244..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1552 AA; 169660 MW; AA308A2EC6AEBCD8 CRC64;
MEPRGAEYFS AQVLQKDVSG RLQAGEELLL YLGAPGAIPD LEDDPSRLAK TVDALTGWVG
SSNYRVSLLG LEILSAFVDR LSTRFKSYVP MVTTALIDRM GDTKEKVREE AQNLALKLMD
EVAPPMYIWE HLASGFKHKN FRSREGVCLC LIETLNIFGT QPLVVSKLVP HLCILFGDSN
SQVRNAAVST VVEIYRHVGE KLKVDLSKRD IPLARLEMIL AKFDEVQNSG GMVLSVCKDK
SFDDEESVDG NRPSSAASAF KVPAPKTSGN PVSSGRKPGS AGGPKVGGAS KEGGAGAVDE
DDFIKAFTDV PSVQIYSSRE LEETLNKIRE ILSDDKHDWD QRANALKKIR SLLVAGAAQY
DCFFQHLRLL DGALKLSAKD LRSQVVREAC ITVAHLSTVL GNKFDHGAEA IVPTLFNLVP
NSAKVMATSG CAAIRFIIRH THVPRLIPLI TSNCTSKSVP VRRRSFEFLD LLLQEWQTHS
LERHAAVLVE TIKKGIHDAD AEARVEARKT YMGLRNHFPG EAETLYNSLE PSYQKSLQTY
LKSSGSVASL PQSDRSSSSS QESLNRPFSS KWSTANPSTV AGRVSVGGSK ASSLPGSLQR
SRSDIDVNAA AGAKAHHAAG QAVRSGRLGA GALNPGSYAS LEDTSDKMDG TASEDGRVRA
KLSAPLAAVG NAKTDSRGRS RTKMVSQSQR SPSPDKNEAG SRSGSPGRVL TTTALSTVSS
GAQRVLVNSA SAQKRSKIPR SQGCSREASP SRLSVARSSR IPRPSVSQGC SREASRESSR
DTSPVRSFQP LASRLHSRST GALYAPDVCG ASGPGYGISQ SSRLSSSVSA MRVLNTGSDV
EEAVADALKK PARRRYESYG MHSDDDANSD ASSACSERSY SSRNGSIPTY MRQTEDVAEV
LNRCASSNWS ERKEGLLGLQ SLLKNQRTLS RVELKRLCEI FTRMFADPHG KRVFSMFLET
LVDFIQVHKD DLQDWLFVLL TQLLKKMGAD LLGSVQAKVQ KALDVTRESF PNDLQFNILM
RFTVDQTQTP SLKTVKPAIR DQLHSFWSSK VKVAILKYIE TLAKQMDPGD FINSSETRLA
VSRVITWTTE PKSSDVRKAA QSVLISLFEL NTPEFTMLLG ALPKTFQDGA TKLLHNHLRN
TGNGTQSSMG SPLTRPTPRS PANWSSPLTS PTNTSQNTLS PSAFDYDTEN MNSEDIYSSL
KGVTEAIQNF SFRSQEDMSE PLKRDPKKED GDTMCGPGMS DPRAGGDAAD SSQTALDNKA
SLLHSMPIHS SSRSRDYNPY NYSDSISPFN KSALKEAMFD DDADQFPDDL SLDHSDLVAE
LLKELSNHNE RIEERKIALY ELMKLTQEES FSVWDEHFKT ILLLLLETLG DKEPTIRALA
LKVLKEILRH QPARFKNYAE LTVMKTLEAH KDPHKEVVRS AEEAASVLAT SISPEQCIKV
LCPIIQTADY PINLAAIKMQ TKVIERVSKE TLNILLPEIM PGLIQGYDNS ESSVRKACVF
CLVAVHAVIG DELKPHLSQL TGSKMKLLNL YIKRAQTGSA GADPTTDVSG QS
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