ID A0A3Q0CUP7_MESAU Unreviewed; 3789 AA.
AC A0A3Q0CUP7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Lysosomal-trafficking regulator isoform X2 {ECO:0000313|RefSeq:XP_021083854.1};
GN Name=Lyst {ECO:0000313|RefSeq:XP_021083854.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021083854.1};
RN [1] {ECO:0000313|RefSeq:XP_021083854.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26319212;
RA Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT "Transcriptome sequencing and development of an expression microarray
RT platform for liver infection in adenovirus type 5-infected Syrian golden
RT hamsters.";
RL Virology 485:305-312(2015).
RN [2] {ECO:0000313|RefSeq:XP_021083854.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_021083854.1; XM_021228195.1.
DR STRING; 10036.ENSMAUP00000002137; -.
DR Proteomes; UP000189706; Unplaced.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2997..3103
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 3108..3410
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3600..3634
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 143..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1168..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2556..2576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2556..2570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3789 AA; 426824 MW; ECFCA63E644C9BA5 CRC64;
MSTDSNSLAR EFLIDVNQLC NAVVQKAEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE QQATDFNLPS SSNIILTKEK NSNLQKSTQG
KLYLEGSAPP GPVSAKINLF RKSRQQRKST HRYSVRDARK TQLSTSDSEG NSDEKSTVVS
KHRRSHVLPR LLLQSPKEDH LIAKLDPSET KEQVLSDTMA LENSREIIPR QDSNGDILSE
PAALSILSNM NNSPFDLCHV LLSLLEKVCK FDIALNHNSS LATSVVPTLT EFLAGFEDCC
NQNDTLEKQV VSSGWTEEPV ALVQRMLFRT VLHLMSVDVS TAEAMPESLR KNLTELLRAA
LKIRAYLEKQ PDPFSPRRKK TLQEVQEGFV FSKYRHRAFL LPELLEGVLQ LLISCLQSAA
SNPFYFSQAM DLVQEFIQHQ GFNLFETAVL QMEWLLSRDG VPSEAAEHLK TLINSIMKII
STVKKVKSEQ LHHSMCTRKR HRRCEYSHFM QHHRDLSGLL VSAFKNQLSK SPFEETAEGD
VQYPERCCCI AVCAHQCLRL LQQVSLSTTC VQILSGVHSV GICCCMDPKS VIIPLLHAFK
LPVLKNFQQH ILNVLNKLLL DQLGGAEISQ RIKKAACNIC TVDSDQLAKL EETLQGTLCG
TGPSSGLSSP SYRFQGILPS SGSEDLLWKW DALEAYQNFV FQEDRLHNIQ IANHICNLIQ
KGNIVVQWKL FNYIFNPVLQ RGVELVHHCQ QLSITSAQTH MCSQLKQCLP QEVLQIYLKT
LPILLKSRAI RDLFLSCNGV NQIIELNYLD GIRSHSLKAF ETLIISLGEQ QKDASVPGVN
GLGMEQELPS LSVSPSFHKQ QASSDSPRSL SKFYASLREA YPKKRKTAYQ DVHVNTINLF
LCVAFLCVSK EADSDRDSAN ESEDTSGYDS TASEPLSHML PCLSLENVVL PSPECLHQAA
DIWSMCRWLY MLSSVFQKQF HRLGGFRVCH ELIFMIIQKL FRSPEEKQGK RQGEVSINEN
QELIRMSQPE MTLKGDVSSS TAPDLGHLKN NAASLNELES QHMFPTSVEQ ILSTEAVAGE
AKAFMSQEND TSLQSIRLLE SLLAICLHSS RASQQKMDLE PPSQSLSVEN ILCEMKEHLS
QSKVTETELA KPLFDALLRV ALGNHSVDLD PGDTVTEKSH QSEEELLSQP GDFSEEIEDS
QCCNLKLLGE EEGYEADSES NPEDGDAQDD GVELKPEAGF SASIVPNTLL ENFTHGEIIY
PEICMLELNL LSASKAKLDV LAHVFESFLR IARQKEKNIS LLMQQGTVKI LLGGFLNILT
QTNSDFQACQ RVLVDLLVSL MSSRTCSEEL TLLLRIFLEK SPCTEILLFG IQKIVESDFT
MSPSQYLTFP LLHTPSLSNG VSPQKSPGIL NSKALGLLRR AKISRGKKEA DRESFPSRLL
SSWHIAPIHL PLLGQNCWPH LSEGFSVSLW FNVEYIHESE SAAERGKKVK KRNKSSILQD
DSFEGAEGDR PEGTEYINPG DRLIEDGCIH LISLGSKALM IQVWADPHSG TFIFRVCMDS
NDDVKAVSLA QAESQENIFF PSKWQHLVLT YLQHPQGKKN VHGEISIWVS GQRKTDVILD
FVLPRKTSLS SDSNKTFCMI GHCLTSQDEF LQLAGKWDLG NLLLFNGAKI GSQEAFYLYA
CGPNFTSIMP CKYGKPVLDY SKYINKEILR CEQIRDLFMT KKGVDVGLLI ESLSVVYTTY
CPAQYTIYEP VIRLKGQVKT QLSQRPFSSK EAQSILLEPS QLKNLWPTEC KTIQGILHEI
GGAGVFVFLF ARVVELSGCE ETQALALRVI LSLIKYSQQR AHELENCNGL SMIHQVLVKQ
KCIVGFHILK TLLEGCCGEE VIHINEHGDF KLDVQSHAII QDVNLLQELL LDWKIWNKAE
KGVWETLLAA LEVLIRAEHE YQQFNIKQLL NAHVVHHFLL TCQVLQEHRE GQLTSLPREV
CRSFVKIIAE VLGSPPDLEL LTIIFNFLLA VHPPTNTYVC HNPINFYFSL HIDGKIFQEK
VQSIMYLRHS SSGGQSFPSP EFLVISPSAF TAAPSEGTSS SNIISQRMDA QMVRSRSLPA
FPTCSLLTQA PKMTGSLGYG IDKLLNVADI HLEKRNPLGS PYTLKTSKEE AFISSCESAR
TVCEMETPLA AQASVSGVSR GTLGFPMPRV DHRDLGTELR LEDDSSVNES YPRRPDNLKG
LASFQRSHST VASLGLAFPS QNGSTAASRW PSLVDRNADD WENFAFSPAY EANYSQAARA
HSVAEDCLIP ICCGLYELLS GVLLILPDAM LEDVMDKIIQ ADTLLVLVNH PSPAIQQGVI
KLLHAYINRA SKEQKDKFLK NRGFSLLANQ LYLHRGTQEL LECFTEMFFG RRIGLDEEYD
LEEVKHMELF QKWSVIPVLG LIESSLYDNV LLHNALLLLL QVLNSCSKVA DMLLDNGLLY
VLCNTVAALN GLEKNIPLNE YKLLACDIQQ LFIAVTIHAC SSSGSQYFRV IEDLIVLLGY
LQNSKNKRTQ NMALALQLRV LQAALEFIRS TANHDSESSV DTVQSPSAHH RTVSQKRRSI
AGPRKFPLAQ TESLLMKMRS VASDELYTMM QRRMSQEHPS QASEAELAQR LQRLTILAVN
RIIYQELNLD IIDILRTPEN AAQIKTSVSQ TEISEEDMHH EQPSIYNPFQ KEMFTYLIDG
FKVSIGSNKT SGCKQQWTKI MGSCKETFRV QLGRLLAHIL SPIHTVQERK QIFEIVHEPA
HQDILRDCLS PSPQHGAKLV LYLSELIHNH QDELNEEELE TAELLLNVLK LCGHKCIPPS
APSKPELIKM IKEEQKKYEN EESVSKGAWQ KTVNNNQQSL FQRLDLKSKD ISKIAADITQ
AISLSQGIER KKVIQHIRGM YKVDLSASRH WQELIHQLTH DRAVWYDPIY YPTSWQLDPT
EGPNRERRRL QRCYLTIPNK YLLRDRQKSE GMVKPPLSYL FEDKTHSSFS STVKDKAASE
SIRVNRRCIS VAPSRETAGE LLLGKCGMYF VEDNASDTVE SSSLQGELEP ASFSWTYEEI
KEVHRRWWQL RDNAVEIFLT NGRTLLLAFD NSKVRDDVYQ SILTNNLPNL LEYGNITALT
NLWYTGQITN FEYLTHLNKH AGRSFNDLMQ YPVFPFILSD YVSETLDLND PSIYRNLSKP
IAVQYKEKED RYVDTYKYLE EEYRKGARED DPMPPVQPYH YGSHYSNSGT VLHFLVRMPP
FTKMFLAYQD QSFDIPDRTF HSTNTTWRLS SFESMTDVKE LIPEFFYLPE FLVNREGFDF
GVRQNGERVN HVNLPPWARN DPRLFILIHR QALESDHVSQ NICHWIDLVF GYKQKGKASV
QAINVFHPAT YFGMDVSAVE DPVQRRALET MIKTYGQTPR QLFHTAHASR PGAKLNIEGE
LPAAVGLLVQ FAFRETREPI KEITYPSPLS WIKGLKWGEY VGSPSAPVPV VCFSQPHGER
FGSLQALPTR AICGLSRNFC LLMTYSKEQG VRSMNNTDIQ WSAILSWGYA DNILRLKSKQ
SEPPINFIQS SQQHQVTSCA WVPDSCQLFT GSKCGVITAY TNRLTNSTPS EIEMESQMHL
YGHTEEITSL CVCKPYSVMI SVSRDGTCIV WDLNRLCYVQ SLAGHKSPVT AVSASETSGD
IATVCDSAGG GSDLRLWTVN GDLVGHVHCR EIICSVAFSN QPEGVSINVI AGGLENGIVR
LWSTWDLKPV REITFPKSNK PIISLTFSCD GHHLYTANSD GTVIAWCRKD QQRMKQPMFY
SFLSSYAAG
//
