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Database: UniProt
Entry: A0A3Q0CV96_MESAU
LinkDB: A0A3Q0CV96_MESAU
Original site: A0A3Q0CV96_MESAU 
ID   A0A3Q0CV96_MESAU        Unreviewed;       585 AA.
AC   A0A3Q0CV96;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Complement component C8 beta chain {ECO:0000256|ARBA:ARBA00013949};
DE   AltName: Full=Complement component 8 subunit beta {ECO:0000256|ARBA:ARBA00031383};
GN   Name=C8b {ECO:0000313|RefSeq:XP_021084074.1};
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021084074.1};
RN   [1] {ECO:0000313|RefSeq:XP_021084074.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Constituent of the membrane attack complex (MAC) that plays a
CC       key role in the innate and adaptive immune response by forming pores in
CC       the plasma membrane of target cells. {ECO:0000256|ARBA:ARBA00002409}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC       {ECO:0000256|ARBA:ARBA00009214}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   RefSeq; XP_021084074.1; XM_021228415.1.
DR   AlphaFoldDB; A0A3Q0CV96; -.
DR   OrthoDB; 4572257at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR048831; C8A_B_C6_EGF-like.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001862; MAC_perforin.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR020863; MACPF_CS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR   PANTHER; PTHR45742:SF5; COMPLEMENT COMPONENT C8 BETA CHAIN; 1.
DR   Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   PRINTS; PR00764; COMPLEMENTC9.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SUPFAM; SSF57424; LDL receptor-like module; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS00279; MACPF_1; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
DR   PROSITE; PS50092; TSP1; 2.
PE   3: Inferred from homology;
KW   Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          153..499
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
FT   REGION          563..585
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        135..150
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   585 AA;  66765 MW;  57B28D4CC238347E CRC64;
     MHYIPYINLP SPHHFGDLRQ WLPVVLRGEK PDFFDTNAAN QNLAKSRQVR NVDITPVPVD
     CELSSWSSWT VCDPCQKKRY RHAYLLRPSQ FHGELCDYSD KEVEDCVTSR PCRKVQCEGF
     VCAQTGRCVN RRLLCNGDND CGDQSDEANC RRIYKKCQHG MEQYWAIGNL ASGINLFTNT
     LEGPVLDHRY YGGGCSPHYI LNTKFRKPYN VEGYTPQTQG NYQFALTEYE SYSDFESNVT
     EKETSKSSFK FGFKIISKFE FGFKEDSNKG RHYISRLKRF SHTKSKFLHA RSVLEVAHYK
     LKSRNLMLHY EFLQRVKSLP LEYSYGEYRD LLRDFGTHFI TEAVLGGIYE YTLIMNKDIM
     EQGDYTFDNI SACVGKQFQI GGAISKVYLK LGVSEKKCND ILNEIKDRNK RNTMVEDLVV
     LVRGGTSEYI TTLAYRELPT AELMREWGDA VQYNPAIIQI KAEPLYELVT AADFAYSSTV
     KQNIKKTLEE FQMEVSSCHC APCQGNGVPV LKGSRCDCIC PAGFQGIACE ITHRKDIPID
     GKWSCWSDWS ACSGGHKTRQ RQCNNPLPQK GGRPCSGPAS ETLNC
//
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