ID A0A3Q0CVV3_MESAU Unreviewed; 872 AA.
AC A0A3Q0CVV3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Nuclear factor of activated T-cells 5 {ECO:0000313|RefSeq:XP_021086455.1};
GN Name=Nfat5 {ECO:0000313|RefSeq:XP_021086455.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021086455.1};
RN [1] {ECO:0000313|RefSeq:XP_021086455.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [2] {ECO:0000313|RefSeq:XP_021086455.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_021086455.1; XM_021230796.1.
DR AlphaFoldDB; A0A3Q0CVV3; -.
DR STRING; 10036.ENSMAUP00000019332; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF10; NUCLEAR FACTOR OF ACTIVATED T-CELLS 5; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 235..414
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 56..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 872
FT /evidence="ECO:0000313|RefSeq:XP_021086455.1"
SQ SEQUENCE 872 AA; 94331 MW; 5E4FD1010F104889 CRC64;
MPSDFISLLS ADLDLESPKS LYSRDSLKLH PSQNFHRAGL LEESVYDLLP KELQLPPPRE
TSVASMSQTS GGEAGSPPPA VVAADASSAP SSSSMGGACS SFTTSSSPTI YSTSVTDSKA
MQVESCSSAV GDEGCGLESE QSCSMWMEDS PSNFSNMSTS SYNDNTEVPR KSRKRNPKQR
PGVKRRDCEE SNMDIFDADS AKAPHYVLSQ LTTDNKGNSK AGNGTLDNQK GTGVKKSPML
CGQYPVKSEG KELKIVVQPE TQHRARYLTE GSRGSVKDRT QQGFPTVKLE GHNEPVVLQV
FVGNDSGRVK PHGFYQACRV TGRNTTPCKE VDIEGTTVIE VGLDPSNNMT LAVDCVGILK
LRNADVEARI GIAGSKKKST RARLVFRVNI IRKDGSTLTL QTPSSPILCT QPAGVPEILK
KSLHSCSVKG EEEVFLIGKN FLKGTKVIFQ ENISDENSWK SEAEIDMELF HQNHLIVKVP
PYHDQHITLP VSVGIYVVTN AGRSHDVQPF TYTPDPAAAG ALNVNVKKEV SSPARPCSFE
EAMKAMKTSG CNLDKVNILP NALITPLISS SMIKTEDVTP MEVTAEKRSP PIFQATKTVG
STQQALETIS NIAGNSSFSS PSSSHLPSEN ENPQQLQPKA YNPETLTTIQ TQDISQPGTF
PAVSASSQLP GSDALLQQAT QFQTRESQSR DTLQSDGTVV NLSQLTEASQ QQQQSPLQEQ
AQTLQQQISS NIFPSPNSVS QLQSTIQHLQ AGSFTGGTAG SSSGSVDLVQ QVLEAQQQLS
SVLFSAPDGN ENVQEQLNAD IFQVSQIQNS VSPGMFSSSE PAVHTRPDNL LPGRADSVHQ
QPENTLSNQQ QQQQQQQQQQ QQQQQQQVQQ LR
//
