ID A0A3Q0CY60_MESAU Unreviewed; 972 AA.
AC A0A3Q0CY60;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
GN Name=LOC101831864 {ECO:0000313|RefSeq:XP_021087124.1,
GN ECO:0000313|RefSeq:XP_021087125.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021087125.1};
RN [1] {ECO:0000313|RefSeq:XP_021087124.1, ECO:0000313|RefSeq:XP_021087125.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR RefSeq; XP_012974190.1; XM_013118736.1.
DR RefSeq; XP_021087124.1; XM_021231465.1.
DR RefSeq; XP_021087125.1; XM_021231466.1.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 22..54
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 83..115
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 126..157
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 719..917
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 362..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 107047 MW; B22A3F7EDE4C1DB2 CRC64;
MSPVLQEDDE KDENIPKMLC QMDNHLACVN CVRWSNSGMY LASGGDDKLI MVWKRATYIG
PSTVFGSSGK LANVEQWRCV SILRSHSGDV MDVAWSPHDA WLASCSVDNT VVIWNAVKFP
EILATLRGHS GLVKGLTWDP VGKYIASQAD DRSLKVWRTL DWQLETSITK PFDECGGTTH
VLRLSWSPDG HYLVSAHAMN NSGPTAQIIE REGWKTNMDF VGHRKAVTVV KFNPKIFKKK
QKNGSSTKPS CPYCCCAVGS KDRSLSVWLT CLKRPLVVIH ELFDKSIMDI SWTLNGLGIL
VCSMDGSVAF LDFSQDELGD PLSEEEKSRI HQSTYGKSLA IMTEAQLSTA VIENPEMLKY
QRRQQQQQLD QKNATARETS SASSVTGVVN GESLEDIRKN LLKKQVETRT ADGRRRITPL
CIAQLDTGDF STAFFNSIPL SSSLAGTMLS SPSSQQLLPL DSSTPSFGAS KPCTEPVAAT
GARPTGESVS KDSMNATSTP AAMSPSVLTT PSKIEPMKAF DSRFTERSKA TPGAPSLTSV
IPTAVERLKD QNLVKELRPR DLLESSSDSD EKVHLVKPSS LSKRKLELEV ETVEKKKKGR
PRKDSRLLPM SLSVQSPAAL TAEKEAMCLS APALALKLPI PGPQRAFTLQ VSSDPCMYIE
VENEVTAVGG IRLSRLKCNR EGKEWETVLT SRVLTAAGSC DVVCVACEKR MLSVFSSCGR
RLLPPILLPS PISTLHCTGS YVMALTAAAT LSVWDVHRQV VVVKEESLHS ILSGSDMTVS
QILLTQHGIP VMNLSDGKAY CFNPSLSTWN LVSDKQDSLA QCADFRNSLP SQDAMLCSGP
LAIIQGRTSN SGRQAARLFS VPHVVQQETT LAYLENQVAA ALTLQSSHEY RHWLLLYARY
LVNEGFEYRL REICKDLLGP VHSSTGSQWE STVVGLRKRE LLKELLPVIG QNLRFQRLFT
ECQEQLDILR DK
//
