ID A0A3Q0D0N2_MESAU Unreviewed; 338 AA.
AC A0A3Q0D0N2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein {ECO:0000256|ARBA:ARBA00015474};
GN Name=Tradd {ECO:0000313|RefSeq:XP_021086346.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021086346.1};
RN [1] {ECO:0000313|RefSeq:XP_021086346.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_021086346.1; XM_021230687.1.
DR AlphaFoldDB; A0A3Q0D0N2; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08780; Death_TRADD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.30.70.680; TRADD, N-terminal domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR035712; TRADD.
DR InterPro; IPR009095; TRADD_N.
DR InterPro; IPR036729; TRADD_N_sf.
DR PANTHER; PTHR14913; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR14913:SF0; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF09034; TRADD_N; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF55044; TRADD, N-terminal domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000313|RefSeq:XP_021086346.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 213..303
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 338 AA; 37747 MW; EE645879A1AD6E72 CRC64;
MAAGQNGHEE WVGSAYLFLE SSMDKVVLSE AYTDPQKKVA IYKALQTALS ESADSPDVLQ
ILKIHCSDPQ LIVQLRFCGR LLCGRFLQAY REGALRSALQ RCMASALAQE AVRLQLELRA
GAEQLDTWLT DEERCLNCIL AQKPDRLRDE ELAELENELR KLTCDCTGQG GDTQVDSAAS
KPLVPSPAEE KLLPAACQTF LFRGQPVVNR PLNLQDQQTF ARSVGLKWRR VGRSLQRSCR
ALRDPALDSL AYEYERDGLY EQAFQLLRRF MQAEGRRATL QRLVEALEEN ELTSLAEDLL
GPAEPDEIRT PPTLLSCWSG TDFPGSQAGI TELQGVHH
//
