ID A0A3Q0D2R8_MESAU Unreviewed; 2333 AA.
AC A0A3Q0D2R8;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Unconventional myosin-XVIIIa isoform X6 {ECO:0000313|RefSeq:XP_021086839.1};
GN Name=Myo18a {ECO:0000313|RefSeq:XP_021086839.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021086839.1};
RN [1] {ECO:0000313|RefSeq:XP_021086839.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR RefSeq; XP_021086839.1; XM_021231180.1.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01386; MYSc_Myo18; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.70.1590; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR036064; MYSc_Myo18.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF13; UNCONVENTIONAL MYOSIN-XVIIIA; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 220..311
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 643..695
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 699..1479
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1018..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1744..1772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2146..2197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2231..2333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..476
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2231..2255
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2278..2293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2295..2310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2311..2333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 792..799
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2333 AA; 261688 MW; 99BF80118DDFB441 CRC64;
MFNLMKKDKD KDGGRKEKKE KKEKKERMSA AELRSLEEMS MRRGFFNLNR SSKRESKTRL
EISNPIPIKV ASGSDLHLTD IDSDSNRGSI ILDSGHLSTA SSSDDLKGEE GSFRGSVLQR
AAKFGSLAKQ NSQMIVKRFS FSQRSRDESA SETSTPSEHS AAPSPQVEVR TLEGQLMQHP
GLGIPRPGPR SRVPELVTKR FPADLRLPAV VPPPPPALRE LELQRRPTGD FGFSLRRTTM
LDRAPEGQAY RRVVHFAEPG AGTKDLALGL VPGDRLVEIN GQNVENKSRD EIVEMIRQSG
DSVRLKVQPI PELSELSRSW LRTGEGHRRE PADVKEEDKT LPKPGSPGKE EGALEGSSKD
SSGPPTSPQP ATSPVPSETS QRAKSPEATL TMNGLGAAST ANEEAPGLSR KRVANAMRKV
VSKVLPGDEE PGNAKEPPGR GAKSPEHPPR GKKGEKAASS PKPPPPPPPP PAPPKPEAKK
EAVKDELSMG LRSLMSRGRG KDHKSRSKQP PGRGEKAPSQ EPGSPEKPGS PDVVDAPKKA
GSPAKPETPN KQCSPAPAQE LVDPDSAGPK SNASGEQQAN SPALGVRQET GADPEVRLSP
AEEAHQRLER IFTASLDPEA ASPAHSQAKT EDQIAAEEAW YETEKVWLVH KDGFSLASQL
KSEQLSLPEG KVRVKLDHDG AILDVDEDDI EKANAPSCDR LEDLASLVYL NESSVLHTLR
QRYGASLLHT YAGTSLLVLS PRGAPAVYSE KVMHMFKGCR REDMAPHIYA VAQTAYRAML
MSRQDQSIVL LGSSGSGKTT SFQHLVQYLA TIAGTSGSKV FSVEKWQALY TLLEAFGNSP
TIMNGSATRF SQILSLDFDQ AGQVASASIQ TMLLEKLRVA RRPASEATFN VFYYLLACGD
STLRTELHLN HLAENNVFGI VPLAKPEEKQ KAAQQFSKLQ TAMKVLAISP EEQKACWLIL
ASIYHLGAAG ATKEAAEAGR KQFARHEWAQ KAAYLLGCSL EELSSAIFKH QLKGGTLQRS
TSFRQGPEES GLGDGTGPKL SAMECLEGMA SGLYSELFTL LISLVNRALK SSQHSLCSMM
IVDTPGFQNP ERGGSARGAS FEELCHNYAQ DRLQRLFHER TFLQELERYK EENIELAFED
LEPATDDSVA AVDQASHQSL VRSLAHADEA RGLLWLLEEE ALVPGATEDT LLDRLFSYYG
PQEGDKKGQS PLLRSSKPRH FLLGHSHGTN WVEYNVSGWL NYTKQNPATQ NASQLLQDSQ
KKIISNLFLG RAGSATVLSG SIAGLEGGSQ LALRRATSMR KTFTTGMAAV KKKSLCIQIK
LQVDALIDTI KRSKMHFVHC FLPVAEGWPG EPRSASSRRV SSSSELDLPP GDPCEAGLLQ
LDVSLLRAQL RGSRLLDAMR MYRQGYPDHM VFSEFRRRFD VLAPHLTKKH GRNYIVMDEK
RAVEELLESL DLEKSSCCMG LSRVFFRAGT LARLEEQRDE QTSRHLTLFQ AACRGYLARQ
HFKKRKIQDL AIRCVQKNIK KNKGVKDWPW WKLFTTVRPL IQVQLSEEQI RNKDEEIQQL
RSKLEKVEKE RNELRLNSDR LETRISELTS ELTDERNTGE SASQLLDAET AERLRAEKEM
KELQTQYDAL KKQMEVMEME VMEARLIRAA EINGDVEDDD AGGEWRLKYE RAVREVDFTK
KRLQQELEDK MEVEQQSRRQ LERRLGDLQA DSDESQRTLQ QLKKKCQRLT AELQDTKLHL
EGQQVRNHEL EKKQRRFDSE LSQAQEETQR EKLQREKLQR EKDMLLAEAF GLKQQLEEKD
MDIAGFTQKV VSLEAELQDI SSQESKDEAS LAKVKKQLRD LEAKVKDQEE ELDEQAGSIQ
MLEQAKLRLE MEMERMRQTH SKEMESRDEE IEEARQSCQK KLKQMEVQLE EEYEDKQKAL
REKRELESKL STLSDQVNQR DYESEKRLRK DLKRTKALLA DAQIMLDHLK NNAPSKREIA
QLKNQLEESE FTCAAAVKAR KAMEVEMEDL HLQIDDIAKA KTALEEQLSR LQREKNEIQN
RLEEDQEDMN ELMKKHKAAV AQASRDMVQM NDLQTQLEES NKEKQELQEK LQALQSQVEF
LEQSMVDKSL VSRQEAKIRE LETRLEFEKT QVKRLESLAS RLKENMEKLT EDRDQRAAAE
NREKEQNKRL QRQLRDTKEE MSELARKEAE ASRKKHELEM DLESLEAANQ SLQADLKLAF
KRIGDLQAAI EDEMESDENE DLINSEGDSD VDSELEDRVD GVKSWLSKNK GPSKAASDDG
SLKSSSPTSH WKSLAPDPSD DERDPADSTS RPRFSHNYLS DSDTEAKPTE TSA
//
