ID A0A3Q0D3B2_MESAU Unreviewed; 2130 AA.
AC A0A3Q0D3B2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Ral GTPase-activating protein subunit alpha-1 isoform X2 {ECO:0000313|RefSeq:XP_021088880.1};
GN Name=Ralgapa1 {ECO:0000313|RefSeq:XP_021088880.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021088880.1};
RN [1] {ECO:0000313|RefSeq:XP_021088880.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26319212;
RA Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT "Transcriptome sequencing and development of an expression microarray
RT platform for liver infection in adenovirus type 5-infected Syrian golden
RT hamsters.";
RL Virology 485:305-312(2015).
RN [2] {ECO:0000313|RefSeq:XP_021088880.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_021088880.1; XM_021233221.1.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 1842..2050
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 343..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1055
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2080..2130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2107..2130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2130 AA; 239480 MW; 3E9650B4D6E04B6F CRC64;
MFSKKPHGDV KKSTQKVLDT KKDALTRLKH LRIVIENAES IDLKQFFDQH FSHIYYVFFE
NFVTIEASLK QKGHKSQREE LDAILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
SLKIRREGVR LFLLWLQALQ DNCSKEQLWM FSCLIPGFSA PQSDYGPRTL DNLINPPLNL
QETQVTIEEV TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQERGFSFL
FSHFKKFYLP YIFPNICKEN SLYHPVLDIP QMRPKPHYVM IKKDAETNEA IYCTKEPFIQ
ARVIVIRWLV SFWLEPKPHS GPNIPGMEGE VLPKNIQRAA ASLVSREENK NDNVDKADKT
TEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRRV FSSKRSNVNF VTEIFRQAFL
LPICEAAAMR KVVKVYQEWI QQEEKPLFMQ EPEERVLSSS DIPCLENVTD HDISIEDGEK
REEENGTNIS EHVRNSSWTK NGSYQDAFHA SEEATEQNIQ AGTQAVLQVF IINSSNIFLL
EPANEIKNLL DEHTDMCKRI LNIYRYMVVQ VSMDKKTWEQ MLLVLLRVTE SVLKMSSQAF
LQFQGKKNMT LAGRLAGPLF QTLIVAWIKA NLNVYISREL WDDLLSVLSS LTYWEELATE
WSLTMETLTK VLARNLYSLD LSDLPLDKLS EQKQKKHKGK GVGHEFQKVS VDKSFSRGWS
RDQPGQAPMR QRSATTTGSP GTEKARSIVR QKTVAMRSRS IGECALPSAY IRSAKSAPVL
IHTSKPFLPD IVLTPLSDEL SDIDDAQILP RSTRVRHFSQ SEDTGNEVFG ALSEEQPLPR
SSSTSDLVEP FTVERAKVNK EDTIPKLPPL NSDTGGSSAN VPDLMDEFIA ERLRSGNAST
MARRGSSPGS LEIPKDLPDI LNKQNQMRPV DDPGVPSEWT SPASAGSSDL MSSDSHSDSF
SAFQCDGRKF DNFGFGTDIG IPSSADVDSG SGHHQSTEEQ EVASLTTLHL DSETSSLNQQ
AFSAEVATVT GSESASPVHS ALGSRSQTPS PSTLNIDHME QKDLQLDEKL HHSVLQTPDD
LEISEFPSEC CSVMAGGTLT GWHADVATVM WRRMLGILGD VNAIMDPEIH AQVFDYLCEL
WQNLAKIRDN LGISADNLTS PSPPVLIPPL RILTPWLFKA TMLTDKYKQG KLHAYKLICN
TMKRRQDVSP NRDFLTHFYN IMHCGLLHID QDIVNTIIKH CSPQFLSLGL PGATMLIMDF
IIAAGRVASS AFLNAPRVEA QVLLGSLVCF PNLYCELPAL HPSIPEIAVS QFTDVKELII
KTVLSSARDE PSGPARCVAL CSLGIWICEE LVHESHHPQI KEALNVICVS LKFTNKTVAH
VACNMLHMLV HYVPRLQIYQ PDSPLKIIQI LIATVTHLLP STEASSYEMD KRLVVSLLLC
LLDWIMALPL KTLLQPVHAT GAENDKTEKS VLNCIYKVLH GCVYGAQCFS NPKYFPISLS
DLASVDYDPF MHLENLKEPE PLHSPDSERS SKLQPVTEVK TQMQQGLISI AARTVITHLV
NHLGHYPMSG GPAMLTSQVC ENHDNHYSES TELSPELFES PNIQFFVLNN TTLVSCIQIR
AEESIPGGGL AAGLVSANSN VRIIVRDLSG KYSWDSAILY GPPIVNSLSE PTSFILSMSH
QEKPEEPPTS NECLEDVTVK DGLSLQLRRF RETVPTWSTI REEEDALDEL LQYLGTTSPE
CLQRTGISLN VPAPQPVCIS EKQENDVINA ILKQYTEEKE FVEKHFNDLN MKASEQDEPT
PQRPQSAFYY CRLLLSILGM NSWDKRRSFH LLKKNEKLLR ELRNLDSRQC RETHKIAVFY
VAEGQEDKYS ILTNIGGSQA YEDFVAGLGW EINLTNHCGF MGGLQKNKST GLTTPYFATS
TVEVIFHVST RMPSDSDDSL TKKLRHLGND EVHIVWSEHT RDYRRGIIPT EFGDVLIVIY
PMKNHMFSIQ IMKKPEVPFF GPLFDGAIVN GKVLPIMVRS TAINASRALK SLIPLYQNFY
EERARYLQTI VQHHLEPTTF EDFAAQVFSP APYHHLPSDA VGSYPESLPS DTPTAAQVDG
ADLASPMSPR TSKSRMSMKL RRSSGSANKS
//
