ID A0A3Q0D3D5_MESAU Unreviewed; 624 AA.
AC A0A3Q0D3D5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rho GTPase-activating protein 22 isoform X5 {ECO:0000313|RefSeq:XP_021087216.1};
GN Name=Arhgap22 {ECO:0000313|RefSeq:XP_021087216.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021087216.1};
RN [1] {ECO:0000313|RefSeq:XP_021087216.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_021087216.1; XM_021231557.1.
DR AlphaFoldDB; A0A3Q0D3D5; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF22; RHO GTPASE-ACTIVATING PROTEIN 22; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 1..55
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 81..275
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68610 MW; FDE74AE190B36FE4 CRC64;
MPFCPTKYLK RNRRPPRGGA GEREKVPANP EALLLMASSQ RDMEDWVQAI RRVIWAPLGG
GTSRSSHAHP VEPLSAGIFG QRLEDTVHHE RKYGPRLAPL LVEQCVDFIR ERGLSEEGLF
RMPGQANLVR DLQDSFDCGE KPLFDSTTDV HTVASLLKLY LRELPEPVIP FARYEDFLSC
AQLLTKDEGE GTLELAKQVS NLPQANYNLL RYICRFLDEV QAHSNVNKMS VQNLATVFGP
NILRPQIEDP VTIMEGTSLV QHLMTVLIRK HGQLFAAASL EEPASPPAAV QRTVEWGSEE
VSSDHQGEPG SPGLPTHRTS SLDGPAAAVL SRTSPQHLGS QTGPAATSPG KRMHSLPGWK
PSFRQGSRSE SPKGGSSSLE VPIISGGNWL INGLSSLRGH RRASSGDRLK DTGSAQRLST
YDNVPPSSHF PSTASMASML WSVASSSREA SVSSCTACRA SDSSACSSLH TEWALEPSPL
ASSSEDHRSP DLGHSLDEAC VGSGSSEPND PGSPTQAHAH RCRALQDQVD ELRAELYQQR
TEYERSLKSI EEGSADLRKQ MSRLEEELDQ ERKKYTMLEI KLRNSERARE DAERRNQLLQ
REMEEFFATL GSLTVGTKGT RAPE
//
