ID A0A3Q0D4A0_MESAU Unreviewed; 589 AA.
AC A0A3Q0D4A0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 3 isoform X6 {ECO:0000313|RefSeq:XP_021087743.1};
GN Name=Rgl3 {ECO:0000313|RefSeq:XP_021087743.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021087743.1};
RN [1] {ECO:0000313|RefSeq:XP_021087743.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_021087743.1; XM_021232084.1.
DR AlphaFoldDB; A0A3Q0D4A0; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF220; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 70..206
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 253..511
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 23..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 65416 MW; C69FF2F9038340D9 CRC64;
MERTAGKELA LAPLQGWGEE TEDGAVYSVS LRRQRSQRST PEGPGDDQVR KRPEAAIPAA
DTFLQYRTSK VRALRAARLE RLVHELVSGD REQDPGFVPA FLATHQAFVP TARVLGFLLP
PPPPPPPPPG VDSKRAERQD QSFSKNLRAV VSVLGSWLRD HPLDFRDPPA HQNLGSVRIF
LDWAAPGGAE AREAEKLLED FLEEAKREQA EEEQRLAWAG PLRAAQSPRS EFVEDFEEEE
SHSSEGPELL DFSVDEVAEQ LTLMDVELFL RVRTCECLGS MWSQRDRPGA AGISPTVRAT
VAQFNAVTSC VLGSVLATPG LAASQRAQRI EKWIRIAQRC RELRNFSSLR AILSALQSNP
IYRLKRSWGA VSREALSTFR KLSQIFSDEN NHLSCRAVLS QEETTEGPHD DGCLPGSLPS
KLPPGPVPYL GTFLTDLVML DTALPDMLKG NLINFEKRRK EWEILARIQQ LQQRCQLYSL
SPRPPVLAAL RAQHQLSEEQ SYRVSRVIEP PAASCPSSPR IRRRISLTKC LRSCPGRRTL
PLVGVPGIHP HQPPVCLQGL LHPVLETETL LLAVLQPPQG PRAPPTSCL
//
