ID A0A3Q0D5U9_MESAU Unreviewed; 540 AA.
AC A0A3Q0D5U9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Hepatocyte nuclear factor 1-alpha isoform X3 {ECO:0000313|RefSeq:XP_021087974.1};
GN Name=Hnf1a {ECO:0000313|RefSeq:XP_021087974.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021087974.1};
RN [1] {ECO:0000313|RefSeq:XP_021087974.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108}.
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DR RefSeq; XP_021087974.1; XM_021232315.1.
DR AlphaFoldDB; A0A3Q0D5U9; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006898; HNF1a_C.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR PANTHER; PTHR11568; HEPATOCYTE NUCLEAR FACTOR 1; 1.
DR PANTHER; PTHR11568:SF4; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; 1.
DR Pfam; PF04813; HNF-1A_C; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 100..181
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 102..182
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 187..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 57065 MW; 38A808148253EAAC CRC64;
MGHSCGECGT QAKLINCCLV RLLRQGLSVE PWLTLNSQRS ACLCLCLCLC SAGIYSTSPP
LAEGGAWLWL GLKTACILEF THAGQGGLIE EPTGDELPTK KGRRNRFKWG PASQQILFQA
YERQKNPSKE ERETLVEECN RAECIQRGVS PSQAQGLGSN LVTEVRVYNW FANRRKEEAF
RHKLAMDTYN GPPPGPGPGA TLSAHSSPGL PTSALSPSKV HGVRYGQPAT SEAAEVPSSS
GGPLVTVSAA LHQVSPTGLE PSSSLLSTEA KLVSATGGPL PPVSTLTALH NLEQTSPGLN
QQPQNLIMAS LPGVMTIGPG EPASLGPTFT NTGASTLVIG LASTQAQSVP VINSMGSSLT
TLQPVQFSQP LHPSYQQPLM PPVQSHVAQS PFMATMAQLQ SPHALYSHKP EVAQYTHTSL
LPQTMLITDT NLSALASLTP TKQGVTLVPQ VFTSDTEASS EPGLHEPSSP ATTIHIPSQD
PSSIQHLQPA HRLSTSPTVS SSSLVLYQSS DSTNGHSHLL PSNHGVIETF ISTQMASSSQ
//
