ID A0A3Q0D6L6_MESAU Unreviewed; 316 AA.
AC A0A3Q0D6L6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Aldo-keto reductase family 1 member B10 {ECO:0000313|RefSeq:XP_021089930.1};
GN Name=Akr1b10 {ECO:0000313|RefSeq:XP_021089930.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021089930.1};
RN [1] {ECO:0000313|RefSeq:XP_021089930.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26319212;
RA Ying B., Toth K., Spencer J.F., Aurora R., Wold W.S.;
RT "Transcriptome sequencing and development of an expression microarray
RT platform for liver infection in adenovirus type 5-infected Syrian golden
RT hamsters.";
RL Virology 485:305-312(2015).
RN [2] {ECO:0000313|RefSeq:XP_021089930.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family.
CC {ECO:0000256|ARBA:ARBA00007905}.
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DR RefSeq; XP_021089930.1; XM_021234271.1.
DR AlphaFoldDB; A0A3Q0D6L6; -.
DR STRING; 10036.ENSMAUP00000011272; -.
DR OrthoDB; 890110at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd19107; AKR_AKR1B1-19; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732:SF278; ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10; 1.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 17..292
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 49
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 111
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 78
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 316 AA; 36189 MW; 1DFEACCC480AAD4C CRC64;
MSTFVELSTK AKMPIVGLGT WQSPPGQVKE AVKAAIDAGY RHIDCAYAYQ NESEVGEAIQ
EKIKEKAVKR EDLFIVSKLW STCFERKLLK EAFQKTLTDL KLDYLDLYLI HWPQGLQPGK
ELFPKDDQGN ILTSKITFLD AWEVMEELVD EGLVKALGIS NFNHFQIERL LNKPGLKHKP
VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPARPW AKPEDPSLLE DPKIKEIAAK
HKKTPAQVLI RFHIQRNVVV IPKSVTPARI RENFQVFDFQ LSDQEMATIL SFNRNWRACL
LPSTVNMEEY PYNAEY
//
