ID A0A3Q0D6T6_MESAU Unreviewed; 2152 AA.
AC A0A3Q0D6T6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dedicator of cytokinesis protein 10 isoform X13 {ECO:0000313|RefSeq:XP_021090005.1};
GN Name=Dock10 {ECO:0000313|RefSeq:XP_021090005.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021090005.1};
RN [1] {ECO:0000313|RefSeq:XP_021090005.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_021090005.1; XM_021234346.1.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd11699; DHR2_DOCK10; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 2.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 169..278
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 660..838
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1678..2138
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 129..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1279..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2152 AA; 246312 MW; 8E999AD707577CE7 CRC64;
MMSFRGKEFW KKRRTVKRVN PEGIHRVSAQ EKPRLLEPLD YETVIEELEK THRNDPLQDL
LFFPSDDFST ATVSWDIRTL YSTVPEEAEH KAESLLVKEA CKFYSSQWYV VNYKYEQYSG
DIRQLPRAEH KPEKLPSHSF EVDHEDADKD EDTTSHSSSK GGGGAGGTGV FKSGWLYKGN
FNSTVNNTVT VRSFKKRYFQ LTQLPDNSYI MNFYKDEKIS KEPKGCIFLD SCTGVVQNNR
LRKYAFELKM NDLTYFVLAA ETESDMDEWI HTLNRILQIS PEGALQGRKS AELAELGLDP
LDNSVTCECT LEETDSSENS LHADFAKYLT ETEETVKTMR NIDRLNLFSL DPDIDTLKLQ
KRDLFENEFV VKPFEEKAAK RIMVICRALN FSLQGSVTEN ENDPVTNIEP FFVSVALYDL
RDSRKISADF HVDLNHPAVR QMLSGAPPAL ENGNIDPGTP RQSEEPHIKG LPEEWLKFPK
QAIFSVSDPH SEIVLVAKVE KVLMGNIGSS AEPYIKNPDS NKFAQKILKS NRQFCSKLGK
YRMPFAWAVR SVFKDNQGNV DRDSRFSPLY RQESSKISAE DLLKLVSDYR RADRIGKMQT
IPGSLDIVVD NIPLEQPNCV TSSFIPVKPF NVMAQSEPTV EVEEFIYDST KYCRPYRVYK
NQIYVYPKHL KYDSQKCFNK ARNITVCIEF KNSDEDGAKP MKCIYGKPGG PLFTSAAYTA
VLHHSQNPDF SDEVKIELPT QLHEKHHLLF SFYHITCDIN AKANAKKKEA LETSVGYAWL
PLMKHDQIAS QEYNIPITTT LPPNYLSIQD SASGKQGGSD IKWVDGGKPL FKVSTFVVST
VNTQDPYVNA FFHQCQKREK DMSQSPTSSF VQACKNLLNV DKIHSIMSFL PIILNQLFKI
LVQNEEEEIS ATITRVLADI VAKCHEEQLD HSVQSYIKFV FKTRSYKERT IHEELTKNLS
DLLKSNDSTI VKHVLKHSWF FFAIILKSMA QHLTDTNKIQ LPRAQRFPES YQSELDNLVM
GLCDHVIWKY KDALEETKRA NHSVARFLKR CFTFMDRGFV FKMVNNYVSM FSSGEFKTLC
QYKFDFLQEV CQHEHFIPLC LPIRSANIPD PLTPSESIQE LHASDMPEYS VTNEFCRKHF
LIGILLREVG FALQEDQDIR HLALAVLKNL MAKHSFDDRY REPRKQAQIA SLYMPLYGML
LDNMPRIYLK DLYPFTVNTS NQGSRDDLST NGGFQTQTSM KHATSVDTSF SKDVLNSIAA
FSSIAISTVN HADSRASLAS LDSNPSTTEK SSEKTDNCEK IPRPLSLIGS TLRFDKLDQA
ETRSLLMCFL HIMKTISVET LIAYWQRAPS PEVSDFFSIL DVCLQNFRYL GKRNIIRKIA
AAFKFVQSTQ NNGTLKGSNP SCQTSGLLSQ WMHTTSGHEG HKQHRSQTLP IIRGKNALSN
PKLLQMLDNT MNSNSNEIDI VHHVDTEANI ATEVCLTILD LLSLFTQVHQ RQLQQSDCQN
SLMKRVFDTY MLFFQVNQSA TALKHVFASL RLFVCKFPSA LFQGPADLCG SFCYEVLKCC
NHRSRSTQME AAALLYFFMR KNFEFNKQRS IVRSHLQLIK AVSQLIADAG IGGSRFQHSL
AITNNFANGD KQMKNSNFPA EVKDLTKRIR TVLMATAQMK EHEKDPEMLV DLQYSLANSY
ASTPELRRTW LESMAKIHAR NGDLSEAAMC YIHIAALIAE YLKRKGYWKM EKICTPPLLP
EDTHPCDSNP LLTTPGGGSM FSMGWPAFLS ITPNIKEEGA MKEDSGMQDT PYNESILVEQ
LYMCVEFLWK SERYELIADV NKPIIAVFEK QRDFKKLSDL YYDIHRSYLK VAEVVNSEKR
LFGRYYRVAF YGQGFFEEEE GKEYIYKEPK LTGLSEISQR LLKLYADKFG ADNVKIIQDS
NKVNPKDLDP KYAYIQVTYV TPFFEEKEIE DRKTDFEMHH NINRFVFETP FTLSGKKHGG
VAEQCKRRTV LTTSHLFPYV KKRIQVISQS STELNPIEVA IDEMSRKVSE LNQLCTTDEV
DMIRLQLKLQ GSVSVKVNAG PMAYARAFLE ETNAKKYPDN QVKLLKEIFR QFADACGQAL
DVNERLIKED QLEYQEELRS HYKDMLSELS AIMNEQLLAQ STETPTEKEH ES
//
