ID A0A3Q0DBU6_MESAU Unreviewed; 451 AA.
AC A0A3Q0DBU6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Ras GTPase-activating protein 3 isoform X2 {ECO:0000313|RefSeq:XP_021090064.1};
GN Name=Rasa3 {ECO:0000313|RefSeq:XP_021090064.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021090064.1};
RN [1] {ECO:0000313|RefSeq:XP_021090064.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_021090064.1; XM_021234405.1.
DR AlphaFoldDB; A0A3Q0DBU6; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR CDD; cd13371; PH_GAP1_mammal-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR037774; RASA3_PH.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF53; RAS GTPASE-ACTIVATING PROTEIN 3; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR PRINTS; PR00402; TECBTKDOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..141
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 193..294
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 451 AA; 51923 MW; AE2EA8D63AAB910C CRC64;
MKLAGMHYLH VTLKPTIEEI CQSHKSCEID PVKLKDGENL ENNMESLRQY VDRIFTVITK
SGVSCPTVMC DIFFSLREAA AKRFQDDLDV RYTAVSSFIF LRFFAPAILS PNLFQLTPHH
TDPQTSRTLT LISKTIQTLG SLSKSKSASF KESYMATFYE FFNEQKYADA VKNFLDLISS
SGRRDPKSIE QPILLKEGFM IKRAQGRKRF GMKNFKKRWF RLTNHEFTYQ KSKGDQPLCS
IPIENILAVE RLEEESFRMK NMFQVIQPER ALYIQANNCV EAKDWIDILT KVSQCNQKRL
TVYHPSAYLN GHWLCCRASS DTAAGCTPCT GGLPANIQLD IDGDRETERI YSLFNLYMGK
LEKMQEACGS KSVYDGPEQE EYSTFIIDDP QETYKTLKQV IAGVGTLEQE HAQYRRDKFK
KTRYGSQEHP IGDKSFQNYI RQQSEISTHS I
//