ID A0A3Q0DCN4_MESAU Unreviewed; 1203 AA.
AC A0A3Q0DCN4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Calcium-activated potassium channel subunit alpha-1 {ECO:0000256|ARBA:ARBA00018044};
DE AltName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE AltName: Full=BKCA alpha {ECO:0000256|ARBA:ARBA00030518};
DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit alpha-1 {ECO:0000256|ARBA:ARBA00030288};
DE AltName: Full=K(VCA)alpha {ECO:0000256|ARBA:ARBA00031597};
DE AltName: Full=KCa1.1 {ECO:0000256|ARBA:ARBA00030652};
DE AltName: Full=Maxi K channel {ECO:0000256|ARBA:ARBA00031999};
DE AltName: Full=Slo-alpha {ECO:0000256|ARBA:ARBA00029583};
DE AltName: Full=Slo1 {ECO:0000256|ARBA:ARBA00030326};
DE AltName: Full=Slowpoke homolog {ECO:0000256|ARBA:ARBA00033447};
GN Name=Kcnma1 {ECO:0000313|RefSeq:XP_021090616.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|Proteomes:UP000189706, ECO:0000313|RefSeq:XP_021090616.1};
RN [1] {ECO:0000313|RefSeq:XP_021090616.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008648}.
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DR RefSeq; XP_021090616.1; XM_021234957.1.
DR AlphaFoldDB; A0A3Q0DCN4; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:UniProt.
DR GO; GO:0005267; F:potassium channel activity; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF28; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303,
KW ECO:0000313|RefSeq:XP_021090616.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 85..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 180..395
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 545..632
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 1024..1144
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 707..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1203 AA; 133706 MW; EE45BE839E094843 CRC64;
MANGGGGGGG SSGGGGDGGG GSGLRMSSNI HANHLSLDAS SSSSSSSSSS SSSSSSSSSV
HEPKMDALII PVTMEVPCDS RGQRMWWAFL ASSMVTFFGG LFIILLWRTL KYLWTVCCHC
GGKTKEAQKI NNGSSQADGT LKPVDEKEEV VAAEVGWMTS VKDWAGVMIS AQTLTGRVLV
VLVFALSIGA LVIYFIDSSN PIESCQNFYK DFTLQIDMAF NVFFLLYFGL RFIAANDKLW
FWLEVNSVVD FFTVPPVFVS VYLNRSWLGL RFLRALRLIQ FSEILQFLNI LKTSNSIKLV
NLLSIFISTW LTAAGFIHLV ENSGDPWENF QNNQALTYWE CVYLLMVTMS TVGYGDVYAK
TTLGRLFMVF FILGGLAMFA SYVPEIIELI GNRKKYGGSY SAVSGRKHIV VCGHITLESV
SNFLKDFLHK DRDDVNVEIV FLHNISPNLE LEALFKRHFT QVEFYQGSVL NPHDLARVKI
ESADACLILA NKYCADPDAE DASNIMRVIS IKNYHPKIRI ITQMLQYHNK AHLLNIPSWN
WKEGDDAICL AELKLGFIAQ SCLAQGLSTM LANLFSMRSF IKIEEDTWQK YYLEGVSNEM
YTEYLSSAFV GLSFPTVCEL CFVKLKLLMI AIEYKSANRE SRILINPGNH LKIQEGTLGF
FIASDAKEVK RAFFYCKACH DDVTDPKRIK KCGCRRLEDE QPPTLSPKKK QRNGGMRNSP
NSSPKLMRHD PLLIPGNDQI DNMDSNVKKY DSTGMFHWCA PKEIEKVILT RSEAAMTVLS
GHVVVCIFGD VSSALIGLRN LVMPLRASNF HYHELKHIVF VGSIEYLKRE WETLHNFPKV
SILPGTPLSR ADLRAVNINL CDMCVILSAN QNNIDDTSLQ DKECILASLN IKSMQFDDSI
GVLQANSQGF TPPGMDRSSP DNSPVHGMLR QPSITTGVNI PIITELAKPG KLPLVSVNQE
KNSGTHILMI TELVNDTNVQ FLDQDDDDDP DTELYLTQPF ACGTAFAVSV LDSLMSATYF
NDNILTLIRT LVTGGATPEL EALIAEENAL RGGYSTPQTL ANRDRCRVAQ LALLDGPFAD
LGDGGCYGDL FCKALKTYNM LCFGIYRLRD AHLSTPSQCT KRYVITNPPY EFELVPTDLI
FCLMQFDHNA GQSRASLSHS SHSSQSSSKK SSSVHSIPST ANRPNRPKSR ESRDKQKKEM
VYR
//